Evidence map›Paper›PMID 30728921›Full record

ArticleJournal of extracellular vesicles2019

Helena Rodriguez-Caro, Rebecca Dragovic, Mengni Shen, Eszter Dombi, Ginny Mounce, Kate Field, Jamie Meadows, Karen Turner, Daniel Lunn, Tim Child and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of extracellular vesicles, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Seminal Vesicle-Derived Exosomes for the Regulation of Sperm Activity.Advances in anatomy, embryology, and cell biology · 2026
    Review
  9. Role of Seminal Exosomes in Reproduction.Journal of cellular physiology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Extracellular vesicles: key mediators inFrontiers in veterinary science · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Helena Rodriguez-CaroNuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, Oxford, UK.ORCID 0000-0003-3907-9660
Rebecca DragovicNuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, Oxford, UK.ORCID 0000-0002-4634-5165
Mengni ShenNuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, Oxford, UK.ORCID 0000-0002-8866-2214
Eszter DombiNuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, Oxford, UK.
Ginny MounceNuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, Oxford, UK.ORCID 0000-0002-3219-8774
Kate FieldOxford Fertility, Institute of Reproductive Sciences, Oxford, UK.
Jamie MeadowsOxford Fertility, Institute of Reproductive Sciences, Oxford, UK.ORCID 0000-0002-5238-6588
Karen TurnerNuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, Oxford, UK.ORCID 0000-0002-2117-7900
Daniel LunnDepartment of Statistics, University of Oxford, Oxford, UK.
Tim ChildNuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, Oxford, UK.
Jennifer Helen SouthcombeNuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, Oxford, UK.ORCID 0000-0003-0699-650X
Ingrid GranneNuffield Department of Women's & Reproductive Health, University of Oxford, Women's Centre, Oxford, UK.ORCID 0000-0002-7056-5723
University of Oxford · GBOxford Fertility · GB

Funding

VERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HILL, JACK · 2006 to 2011
$14.5M
Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8M
NCRR NIH HHS P20 RR021905NIGMS NIH HHS P30 GM118228
6 · The paper itself

Abstract

Extracellular vesicles are highly abundant in seminal fluids and have a known role enhancing sperm function. Clinical pregnancy rates after IVF treatment are improved after female exposure to seminal fluid. Seminal fluid extracellular vesicles (SF-EVs) are candidate enhancers, however, whether SF-EVs interact with cells from the endometrium and modulate the implantation processes is unknown. Here, we investigated whether SF-EVs interact with endometrial stromal cells (ESCs) and enhance decidualisation, a requisite for implantation. SF-EVs, isolated from human seminal fluid (

Indexed as

endometriumExosomesprolactinprostasomesreceptivity

Identifiers

PMID30728921
PMCPMC6352950
OpenAlexW2914419976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.