Evidence map›Paper›PMID 30728910›Full record

ArticleOncotarget2019

Improved survival outcomes and relative youthfulness of multiple myeloma patients with t(4;14) receiving novel agents are associated with poorer performance of the revised international staging system in a real aging society.

Yoshiaki Abe, Kazutaka Sunami, Takeshi Yamashita, Mikio Ueda, Hiroyuki Takamatsu, Kentaro Narita, Hiroki Kobayashi, Akihiro Kitadate, Masami Takeuchi, Kosei Matsue

Abstract read
In one paragraph

Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yoshiaki AbeDivision of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, Chiba, Japan.
Kazutaka SunamiDepartment of Hematology, National Hospital Organization Okayama Medical Center, Okayama, Japan.
Takeshi YamashitaDepartment of Internal Medicine, Keiju Kanazawa Hospital, Ishikawa, Japan.
Mikio UedaDepartment of Internal Medicine, Keiju Kanazawa Hospital, Ishikawa, Japan.
Hiroyuki TakamatsuDepartment of Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.
Kentaro NaritaDivision of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, Chiba, Japan.
Hiroki KobayashiDivision of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, Chiba, Japan.
Akihiro KitadateDivision of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, Chiba, Japan.
Masami TakeuchiDivision of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, Chiba, Japan.
Kosei MatsueDivision of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Revised International Staging System (R-ISS) was developed for a more accurate risk stratification of patients with symptomatic multiple myeloma (MM). However, original and subsequent validation studies of the R-ISS included relatively younger patients, many of whom were treated without bortezomib. Hence, we investigated the real-world prognostic performance of the R-ISS in 400 patients with MM treated with novel agents in Japan, an aging society. The patients had a median age of 72 years, and 96.0% were treated with bortezomib. Patients in R-ISS stage II were significantly older and failed to show significantly longer overall survival (OS) compared to patients in R-ISS stages III (median age; 74 and 70 years, respectively;

Indexed as

agingmultiple myelomaprognosisrevised international staging systemt(4;14)

Identifiers

PMID30728910
PMCPMC6355174

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.