Evidence map›Paper›PMID 30728855›Full record

ArticleSource code for biology and medicine2019

eUTOPIA: solUTion for Omics data PreprocessIng and Analysis.

Veer Singh Marwah, Giovanni Scala, Pia Anneli Sofia Kinaret, Angela Serra, Harri Alenius, Vittorio Fortino, Dario Greco

Abstract read
In one paragraph

Article in Source code for biology and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
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  16. Bet v 1 triggers antiviral-type immune signalling in birch-pollen-allergic individuals.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
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  20. Nextcast: A software suite to analyse and model toxicogenomics data.Computational and structural biotechnology journal · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Veer Singh Marwah1Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
Giovanni Scala1Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
Pia Anneli Sofia Kinaret1Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
Angela Serra1Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
Harri Alenius4Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Vittorio Fortino6Institute of Biomedicine, University of Eastern Finland (Kuopio Campus), FI-70210 Kuopio, Finland.
Dario Greco1Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.ORCID 0000-0001-9195-9003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApplication of microarrays in omics technologies enables quantification of many biomolecules simultaneously. It is widely applied to observe the positive or negative effect on biomolecule activity in perturbed versus the steady state by quantitative comparison. Community resources, such as Bioconductor and CRAN, host tools based on R language that have become standard for high-throughput analytics. However, application of these tools is technically challenging for generic users and require specific computational skills. There is a need for intuitive and easy-to-use platform to process omics data, visualize, and interpret results.

resultsWe propose an integrated software solution, eUTOPIA, that implements a set of essential processing steps as a guided workflow presented to the user as an R Shiny application.

conclusionseUTOPIA allows researchers to perform preprocessing and analysis of microarray data via a simple and intuitive graphical interface while using state of the art methods.

Indexed as

Gene expressionMicroarrayR shinyTranscriptomics analysis

Identifiers

PMID30728855
PMCPMC6352382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.