ArticleNature2019
The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis.
Abstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 3 pooled it
27.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
195 citing papers in PubMed, 3 syntheses or guidelines pooled it, 319 citations in OpenAlex.
- The association between dyslipidemia and hand osteoarthritis: a systematic review and meta-analysis.Clinical rheumatology · 2025Pooled it
- The association between statin use and osteoarthritis-related outcomes: An updated systematic review and meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review.BMC complementary medicine and therapies · 2021Pooled it
- lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.Pharmaceutical biology · 2026Article
- The retinoic acid-related orphan receptors (RORs) signaling axis in skeletal homeostasis: mechanistic insights and chronotherapeutic prospects.Annals of medicine · 2026Review
- Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review).International journal of molecular medicine · 2026Review
- Engineered Cyanobacteria-Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanism of RORα in promoting osteoarthritis through p53 deubiquitination-mediated chondrocyte ferroptosis.iScience · 2026Article
- Metabolic disorders and osteoarthritis: novel insights into pathological mechanisms and therapeutic strategies.Life medicine · 2026Review
- MFAP5iScience · 2026Article
- DCLK1-dependent NF-κB activation mediates p-STAT3-induced osteoarthritis progression.Clinical and translational medicine · 2026Article
- Oxysterol undersulfation promotes osteoarthritis by fueling chondrocyte lipid accumulation.Nature communications · 2026Article
- Interleukin-1β-induced arthritis involves chondrocyte oxiapoptophagy.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026Article
- Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFD-MAC cascade.Bone research · 2026Article
- Automated Objective Scoring of Osteoarthritis Severity in Mouse Medial Tibial Cartilage Using Deep Learning.Cartilage · 2026Article
- Chondrocytes reprogram chromatin in hypoxic microenvironments to activate CADM1-AS1/HDAC1 complex-mediated anti-inflammation signals.Nature communications · 2026Article
- Exosome-mediated cholesterol flow drives scoliosis progression via promoting the spinal cartilage-bone positive feedback.Communications biology · 2026Article
- Single-cell and spatial profiling of peripheral blood and synovium unveils pro-arthritis CNBPJournal of translational medicine · 2026Article
- Variations in Haematological and Biochemical Indices in Aggressive Periodontitis: A Case-Control Study in Ghana.Health science reports · 2026Article
- Valvular Leaflets Are Not Innocent Bystanders: Divergent Fibrotic Remodeling Accompanies Functional Mitral and Tricuspid Regurgitation.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
135 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Wan-Su ChoiNational Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Gyuseok LeeNational Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Won-Hyun SongDepartment of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, South Korea.
Jeong-Tae KohDepartment of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, South Korea.
Jiye YangNational Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Ji-Sun KwakNational Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Hyo-Eun KimNational Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Seul Ki KimNational Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Young-Ok SonNational Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Hojung NamSchool of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Iljung JinSchool of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Zee-Yong ParkSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Jiyeon KimSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
In Young ParkDivision of Rheumatology, Hallym University Sacred Heart Hospital, Kyunggido, South Korea.
Jeong-Im HongDivision of Rheumatology, Hallym University Sacred Heart Hospital, Kyunggido, South Korea.
Hyun Ah KimDivision of Rheumatology, Hallym University Sacred Heart Hospital, Kyunggido, South Korea.
Churl-Hong ChunDepartment of Orthopedic Surgery, Wonkwang University School of Medicine, Iksan, South Korea.
Je-Hwang RyuDepartment of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju, South Korea. jesryu@jnu.ac.kr.
Jang-Soo ChunNational Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea. jschun@gist.ac.kr.
Gwangju Institute of Science and Technology · KRChonnam National University · KRHallym University Sacred Heart Hospital · KRWonkwang University · KR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis-the most common form of age-related degenerative whole-joint disease
Indexed as
AnimalsBiological TransportCholesterolChondrocytesCytochrome P450 Family 7MaleMiceNuclear Receptor Subfamily 1, Group F, Member 1OsteoarthritisOxysterolsSteroid HydroxylasesUp-RegulationCholesterolcholesterol 25-hydroxylaseCyp7b1 protein, mouseCytochrome P450 Family 7Nuclear Receptor Subfamily 1, Group F, Member 1OxysterolsSteroid Hydroxylases
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.