Evidence map›Paper›PMID 30728497›Full record

ArticleNature2019

Directionality of dynein is controlled by the angle and length of its stalk.

Sinan Can, Samuel Lacey, Mert Gur, Andrew P Carter, Ahmet Yildiz

Abstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Characterizing dynamics of productive dynein stepping by MINFLUX.Nature structural & molecular biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Understanding hypertrophic cardiomyopathy and its regulation by myosin drugs.Protein science : a publication of the Protein Society · 2025
    Article
  8. Article
  9. The mechanochemical cycle of reactive full-length human dynein 1.Nature structural & molecular biology · 2025
    Article
  10. Review
  11. A logistic regression model to predict long-term survival for borderline resectable pancreatic cancer patients with upfront surgery.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  12. Article
  13. Article
  14. On the Control of Directionality of Myosin.Journal of the American Chemical Society · 2024
    Article
  15. Stepping dynamics of dynein characterized by MINFLUX.bioRxiv : the preprint server for biology · 2024
    Article
  16. The mechanism and energetics of the dynein priming stroke.Structure (London, England : 1993) · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sinan CanPhysics Department, University of California at Berkeley, Berkeley, CA, USA.
Samuel LaceyMedical Research Council, Laboratory of Molecular Biology, Division of Structural Studies, Cambridge, UK.
Mert GurDepartment of Mechanical Engineering, Istanbul Technical University, Istanbul, Turkey.
Andrew P CarterMedical Research Council, Laboratory of Molecular Biology, Division of Structural Studies, Cambridge, UK.
Ahmet YildizPhysics Department, University of California at Berkeley, Berkeley, CA, USA. yildiz@berkeley.edu.

Funding

Understanding the Mechanism and Regulation of the Human Cytoplasmic Dynein ComplexR01GM094522 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI YILDIZ, AHMET · 2011 to 2019
$2.8M
Structural and Functional Characterization of Telomere Protection and MaintenanceR01GM118773 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI YILDIZ, AHMET · 2016 to 2019
$1.2M
Medical Research Council MC_UP_A025_1011NIGMS NIH HHS R01 GM094522NIGMS NIH HHS R01 GM118773
6 · The paper itself

Abstract

The ability of cytoskeletal motors to move unidirectionally along filamentous tracks is central to their role in cargo transport, motility and cell division. Kinesin and myosin motor families have a subclass that moves towards the opposite end of the microtubule or actin filament with respect to the rest of the motor family

Indexed as

Cryoelectron MicroscopyMolecular Dynamics SimulationMovementSaccharomyces cerevisiaeDyneinsMicrotubulesModels, BiologicalNucleotidesProlineSingle Molecule ImagingDyneinsNucleotidesProline

Identifiers

PMID30728497
PMCPMC6450657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.