ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review.Pharmacological reviews · 2022Pooled it
- A cognitive computational framework for ovarian hormone modulation of addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Remifentanil self-administration promotes circuit- and sex-specific adaptations within the prefrontal-accumbens pathways.bioRxiv : the preprint server for biology · 2026Article
- High incidence of estrous cycle irregularities in heterogeneous stock (HS) rats is associated with footshock-resistant cocaine intake.Psychopharmacology · 2026Article
- Estrous cycle stage gates the effect of stress on reward learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The lateral septum orchestrates state-dependent modulation of associative threat memory dynamics across the ovarian hormone cycle.bioRxiv : the preprint server for biology · 2026Article
- Remifentanil self-administration promotes circuit- and sex-specific adaptations within the prefrontal-accumbens pathways.Frontiers in cellular neuroscience · 2026Article
- Effects of sex and estrous cycle on action-outcome contingencies.Behavioural brain research · 2025Article
- Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages.Frontiers in behavioral neuroscience · 2025Review
- Sex and estradiol effects in the rodent dorsal striatum.The European journal of neuroscience · 2024Review
- Acute, but not repeated, cocaine exposure alters allopregnanolone levels in the midbrain of male and female rats.Psychopharmacology · 2024Article
- Acquired Alterations in Nucleus Accumbens Responsiveness to a Cocaine-Paired Discriminative Stimulus Preceding Rats' Daily Cocaine Consumption.Addiction neuroscience · 2023Article
- Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking.Scientific reports · 2023Article
- Estrous cycle dependent expression of oxycodone conditioned reward in rats.Scientific reports · 2023Article
- ΔAddiction biology · 2023Article
- Effects of sex and estrous cycle on intravenous oxycodone self-administration and the reinstatement of oxycodone-seeking behavior in rats.bioRxiv : the preprint server for biology · 2023Article
- Article
- Preventing incubation of drug craving to treat drug relapse: from bench to bedside.Molecular psychiatry · 2023Review
- Structured tracking of alcohol reinforcement (STAR) for basic and translational alcohol research.Molecular psychiatry · 2023Article
- Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect.Pharmacological reviews · 2023Review
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8 authors at 2 institutions in 1 country.
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Abstract
While preclinical work has aimed to outline the neural mechanisms of drug addiction, it has overwhelmingly focused on male subjects. There has been a push in recent years to incorporate females into existing addiction models; however, males and females often have different behavioral strategies, making it important to not only include females, but to develop models that assess the factors that comprise female drug addiction. Traditional self-administration models often include light or tone cues that serve as discriminative stimuli and/or consequent stimuli, making it nearly impossible to disentangle the effects of cue learning, the cues themselves, and acute effects of psychostimulant drugs. To disentangle the interaction between drug-associated cues and the consummatory and appetitive responding driven by cocaine, we have developed a new behavioral procedure that combines Pavlovian-instrumental transfer with behavioral economic analysis. This task can be completed within a single session, allowing for studies looking at estrous cycle stage-dependent effects in intact cycling females, something that has been difficult in the past. In this study, we found no differences in self-administration across the estrous cycle in the absence of cues; however, when cues were introduced, the cues that acquired value during estrus-but not during diestrus or in males-increased motivation. Cues paired during estrus also increased c-fos expression to a greater extent in striatal regions, an effect that may underlie the observed increases in seeking induced by these cues, even weeks later. Together, these data suggest that fundamental differences in the motivational properties of psychostimulant drugs between males and females are complex and are driven primarily by the interaction between drug-associated stimuli and drug effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.