ArticleScientific reports2019
The cytochrome P450 CYP6DE1 catalyzes the conversion of α-pinene into the mountain pine beetle aggregation pheromone trans-verbenol.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 47 citations in OpenAlex.
- A Selective Sweep Likely Linked to Xenobiotic Detoxification Identified Along Altitudinal Gradients in the Pine Processionary Moth.Genome biology and evolution · 2026Article
- Identification and catalytic optimization of pinene oxidases in paeoniflorin biosynthetic pathway.Plant physiology · 2026Article
- Identification and Characterization of the Detoxification Genes from the Transcriptome ofInsects · 2026Article
- A Plant-Based Platform for the Production of Bark Beetle Pheromones.Plant biotechnology journal · 2026Article
- Microbial Mediators of Pine Defense Resistance: Stage-Specific Gut Symbionts Enable Acantholyda posticalis to Overcome Terpenoid Barriers.Microbial ecology · 2026Article
- Pine monoterpenes drive growth, competition, and volatile metabolism of symbiotic fungi associated with the mountain pine beetle.FEMS microbiology letters · 2026Article
- Complex Roles of Insect Cytochrome P450s in Chemical Adaptation.International journal of biological sciences · 2026Review
- Hydroxylases involved in terpenoid biosynthesis: a review.Bioresources and bioprocessing · 2023Review
- Theoretical Study of Hydroxylation of α- and β-Pinene by a Cytochrome P450 Monooxygenase Model.International journal of molecular sciences · 2023Article
- Evolution and functional role prediction of the CYP6DE and CYP6DJ subfamilies inFrontiers in molecular biosciences · 2023Article
- Antennae-enriched expression of candidate odorant degrading enzyme genes in the turnip aphid,Frontiers in physiology · 2023Article
- Activation of the ROS/CncC Signaling Pathway Regulates Cytochrome P450International journal of molecular sciences · 2022Article
- Identification and Defensive Characterization ofInternational journal of molecular sciences · 2022Article
- Gut transcriptome of two bark beetle species stimulated with the same kairomones reveals molecular differences in detoxification pathways.Computational and structural biotechnology journal · 2022Article
- Antennae-abundant expression of candidate cytochrome P450 genes associated with odorant degradation in the asian citrus psyllid,Frontiers in physiology · 2022Article
- Identification of Fungal Limonene-3-Hydroxylase for Biotechnological Menthol Production.Applied and environmental microbiology · 2021Article
- Identification of genes and gene expression associated with dispersal capacity in the mountain pine beetle,PeerJ · 2021Article
- The Differential Expression of Mevalonate Pathway Genes in the Gut of the Bark BeetleInternational journal of molecular sciences · 2019Article
- Time-Course of CYP450 Genes Expression From Dendroctonus rhizophagus (Curculionidae: Scolytinae) During Early Hours of Drilling Bark and Settling Into the Host Tree.Journal of insect science (Online) · 2019Article
- An Overview of Genes FromFrontiers in microbiology · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The recent outbreak of the mountain pine beetle (Dendroctonus ponderosae; MPB) has affected over 20 M hectares of pine forests in western North America. During the colonization of host trees, female MPB release the aggregation pheromone (-)-trans-verbenol. (-)-trans-Verbenol is thought to be produced from the pine defense compound (-)-α-pinene by cytochrome P450 (P450) dependent hydroxylation. MPB may also use P450s for the detoxification of other monoterpenes of the pine defense system. Here we describe the functional characterization of MPB CYP6DE1. CYP6DE1, but not the closely related CYP6DE2, used the bicyclic monoterpenes (-)-α-pinene, (+)-α-pinene, (-)-β-pinene, (+)-β-pinene and (+)-3-carene as substrates. CYP6DE1 was not active with other monoterpenes or diterpene resin acids that were tested as substrates. trans-Verbenol is the major product of CYP6DE1 activity with (-)-α-pinene or (+)-α-pinene as substrates. When tested with blends of different ratios of (-)-α-pinene and (+)-α-pinene, CYP6DE1 produced trans-verbenol with an enantiomeric profile that was similar to that produced by female MPB exposed to the α-pinene enantiomers.
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