ArticleNature communications2019
Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Multimodal investigation of the association between shift work and the brain in a population-based sample of older adults.Scientific reports · 2022Trial
- Transcriptome Analysis of Hippocampus After Weekly Binge Alcohol Exposure and Voluntary Exercise in Rats.Alcohol, clinical & experimental research · 2026Article
- The brain network underlying social participation: a multimodal, data-driven investigation.Brain imaging and behavior · 2026Article
- Evaluating MRI correlates of lifestyle-based dementia risk reduction: Results from the AgeWell.de imaging study.Journal of Alzheimer's disease : JAD · 2026Article
- Genome-Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Differences in cortical gyrification and fractional amplitude of low-frequency fluctuations between early- and late-onset obsessive-compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2026Article
- A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study.Journal of otology · 2025Article
- Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults.Aging and disease · 2025Article
- Cardiovascular risk factors modulate the effect of brain imaging-derived phenotypes on ischaemic stroke risk.Brain communications · 2025Article
- Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance.Frontiers in psychology · 2025Article
- Climate geroscience: the case for 'wisdom-inquiry' science.Biology letters · 2024Article
- Higher surface folding of the human premotor cortex is associated with better long-term learning capability.Communications biology · 2024Article
- The interaction effects of age, APOE and common environmental risk factors on human brain structure.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The association between cortical gyrification and sleep in adolescents and young adults.Sleep · 2024Article
- Exploring the relationship between physical activity and cognitive function: an fMRI pilot study in young and older adults.Frontiers in public health · 2024Article
- The association between cortical gyrification and sleep in adolescents and young adults.bioRxiv : the preprint server for biology · 2023Article
- Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer's disease.Scientific reports · 2023Article
- Age-dependent changes in the dynamic functional organization of the brain at rest: a cross-cultural replication approach.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Lifestyle risks associated with brain functional connectivity and structure.Human brain mapping · 2023Article
- Overview on brain function enhancement of Internet addicts through exercise intervention: Based on reward-execution-decision cycle.Frontiers in psychiatry · 2023Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain structure and functional connectivity in a population-based cohort of 549 older adults. A combined lifestyle risk score was associated with decreased gyrification in left premotor and right prefrontal cortex, and higher functional connectivity to sensorimotor and prefrontal cortex. While structural differences were driven by alcohol consumption, physical activity, and social integration, higher functional connectivity was driven by smoking. Results suggest that combining differentially contributing lifestyle variables may be more than the sum of its parts. Associations generally were neither altered by adjustment for genetic risk, nor by depressive symptomatology or education, underlining the relevance of daily habits for brain health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.