Evidence map›Paper›PMID 30728252›Full record

ArticleJournal of virology2019

Punctuated Evolution of Myxoma Virus: Rapid and Disjunct Evolution of a Recent Viral Lineage in Australia.

Peter J Kerr, John-Sebastian Eden, Francesca Di Giallonardo, David Peacock, June Liu, Tanja Strive, Andrew F Read, Edward C Holmes

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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  12. Mutational spectrum of SARS-CoV-2 during the global pandemic.Experimental & molecular medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Peter J KerrCSIRO Health and Biosecurity, Canberra, Australian Capital Territory, Australia.
John-Sebastian EdenMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Francesca Di GiallonardoThe Kirby Institute, University of New South Wales, Randwick, New South Wales, Australia.
David PeacockBiosecurity SA, Adelaide, South Australia, Australia.
June LiuCSIRO Health and Biosecurity, Canberra, Australian Capital Territory, Australia.
Tanja StriveCSIRO Health and Biosecurity, Canberra, Australian Capital Territory, Australia.
Andrew F ReadCenter for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, USA.
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia edward.holmes@sydney.edu.au.ORCID 0000-0001-9596-3552
CSIRO Health and Biosecurity · AUThe University of Sydney · AUPennsylvania State University · USUNSW Sydney · AU

Funding

Genomic analysis of the canonical case of virulence evolution: Myxomatosis in AuR01AI093804 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI READ, ANDREW F. · 2012 to 2016
$2.7M
NIAID NIH HHS R01 AI093804
6 · The paper itself

Abstract

Myxoma virus (MYXV) has been evolving in a novel host species-European rabbits-in Australia since 1950. Previous studies of viruses sampled from 1950 to 1999 revealed a remarkably clock-like evolutionary process across all Australian lineages of MYXV. Through an analysis of 49 newly generated MYXV genome sequences isolated in Australia between 2008 and 2017, we show that MYXV evolution in Australia can be characterized by three lineages, one of which exhibited a greatly elevated rate of evolutionary change and a dramatic breakdown of temporal structure. Phylogenetic analysis revealed that this apparently punctuated evolutionary event occurred between 1996 and 2012. The branch leading to the rapidly evolving lineage contained a relatively high number of nonsynonymous substitutions, and viruses in this lineage reversed a mutation found in the progenitor standard laboratory strain (SLS) and all previous sequences that disrupts the reading frame of the

Indexed as

Evolution, MolecularGenes, ViralOpen Reading FramesPhylogenyPoxviridae InfectionsAnimalsAustraliaMyxoma virusRabbitsTime FactorsViral ProteinsWhole Genome SequencingViral ProteinsAustraliaevolutionmyxoma virusnatural selectionphylogenyrabbit

Identifiers

PMID30728252
PMCPMC6450118
OpenAlexW2952175124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.