Evidence map›Paper›PMID 30728247›Full record

ArticleThe Journal of biological chemistry2019

Functional genomics of epilepsy-associated mutations in the GABA

Nathan L Absalom, Philip K Ahring, Vivian W Liao, Thomas Balle, Tian Jiang, Lyndsey L Anderson, Jonathon C Arnold, Iain S McGregor, Michael T Bowen, Mary Chebib

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Understanding paralogous epilepsy-associated GABAProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. GABAJournal of neurochemistry · 2024
    Review
  7. Review
  8. Article
  9. Genetic Background of Epilepsy and Antiepileptic Treatments.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Significance of GABAInternational journal of molecular sciences · 2021
    Review
  15. Intricacies of GABAInternational journal of molecular sciences · 2021
    Review
  16. Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors.Cellular and molecular life sciences : CMLS · 2021
    Article
  17. Regulation of GABATrends in neurosciences · 2021
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nathan L AbsalomFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; School of Pharmacy, University of Sydney, Camperdown, New South Wales 2006, Australia.
Philip K AhringFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; School of Pharmacy, University of Sydney, Camperdown, New South Wales 2006, Australia.
Vivian W LiaoFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; School of Pharmacy, University of Sydney, Camperdown, New South Wales 2006, Australia.
Thomas BalleFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; School of Pharmacy, University of Sydney, Camperdown, New South Wales 2006, Australia.
Tian JiangFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; School of Pharmacy, University of Sydney, Camperdown, New South Wales 2006, Australia.
Lyndsey L AndersonFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; Discipline of Pharmacology, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales 2006, Australia; Lambert Initiative for Cannabinoid Therapeutics, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia.
Jonathon C ArnoldFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; Discipline of Pharmacology, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales 2006, Australia; Lambert Initiative for Cannabinoid Therapeutics, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia.
Iain S McGregorFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; Lambert Initiative for Cannabinoid Therapeutics, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; the School of Psychology, Faculty of Science, University of Sydney, Camperdown, New South Wales 2006, Australia.
Michael T BowenFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; Lambert Initiative for Cannabinoid Therapeutics, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; the School of Psychology, Faculty of Science, University of Sydney, Camperdown, New South Wales 2006, Australia.
Mary ChebibFrom the Brain and Mind Centre, University of Sydney, 94 Mallett Street, Camperdown, New South Wales 2050, Australia; School of Pharmacy, University of Sydney, Camperdown, New South Wales 2006, Australia. Electronic address: mary.collins@sydney.edu.au.
University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of epilepsy-causing mutations have recently been identified in the genes of the α1, β3, and γ2 subunits comprising the γ-aminobutyric acid type A (GABA

Indexed as

Cell MembraneEpilepsyMutation, MissenseProtein SubunitsReceptors, GABA-AAmino Acid SubstitutionAnimalsgamma-Aminobutyric AcidHumansXenopus laevisgamma-Aminobutyric AcidProtein SubunitsReceptors, GABA-Abrain disorderchannel activationconcatemercryo-electron microscopyepilepsyGABA receptorheterozygousmissenseneurotransmissionneurotransmittersynaptic transmission

Identifiers

PMID30728247
PMCPMC6463728
OpenAlexW2913873074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.