ArticleDiabetes care2019
Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct: A Mendelian Randomization Study.
Article in Diabetes care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pooled it
- Pooled it
- Genetically Predicted Milk Intake Increased Femoral Neck Bone Mineral Density in Women But Not in Men.Frontiers in endocrinology · 2022Pooled it
- Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals.International journal of obesity (2005) · 2021Pooled it
- Article
- Lactase Persistence-Associated rs4988235 Polymorphism: A Novel Genetic Link to Cardiovascular Risk via Modulation of ApoB100 and ApoAI.Nutrients · 2025Article
- Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK.Nature communications · 2025Article
- The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study.Archives of medical science : AMS · 2024Article
- Milk and dairy products - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- Associations of intakes of total protein, protein from dairy sources, and dietary calcium with risks of colorectal, breast, and prostate cancer: a prospective analysis in UK Biobank.British journal of cancer · 2023Article
- Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges.Diabetologia · 2023Review
- Association between frequency of dairy product consumption and hypertension: a cross-sectional study in Zhejiang Province, China.Nutrition & metabolism · 2022Article
- Using genetic variation to disentangle the complex relationship between food intake and health outcomes.PLoS genetics · 2022Article
- Changes in intake of dairy product subgroups and risk of type 2 diabetes: modelling specified food substitutions in the Danish Diet, Cancer and Health cohort.European journal of nutrition · 2021Article
- Article
- Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study.BMC medicine · 2020Article
- Milk Consumption for the Prevention of Fragility Fractures.Nutrients · 2020Review
- Dairy product consumption and hypertension risk in a prospective French cohort of women.Nutrition journal · 2020Article
- Changes in dairy product consumption and risk of type 2 diabetes: results from 3 large prospective cohorts of US men and women.The American journal of clinical nutrition · 2019Article
- Guidelines for performing Mendelian randomization investigations: update for summer 2023.Wellcome open research · 2019Article
Corrections and comments
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Authors and funding
36 authors at 20 institutions in 9 countries.
Funding
Abstract
objectiveTo estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND
methodsThe analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression.
resultsEach additional LP allele was associated with a higher intake of milk (β 17.1 g/day, 95% CI 10.6-23.6) and milk beverages (β 2.8 g/day, 95% CI 1.0-4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (β -7.0 g/day, 95% CI -12.4 to -1.7 per additional LP allele), nonalcoholic beverages (β -18.0 g/day, 95% CI -34.4 to -1.6), and wine (β -4.8 g/day, 95% CI -9.1 to -0.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratio
conclusionsrs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations, we consider it unlikely that this caused the observed null result.
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