Evidence map›Paper›PMID 30728043›Full record

ArticleTrials2019

Converting habits of antibiotic use for respiratory tract infections in German primary care - study protocol of the cluster-randomized controlled CHANGE-3 trial.

Anja Wollny, Attila Altiner, Tonia Brand, Katharina Garbe, Martina Kamradt, Petra Kaufmann-Kolle, Mirko Leyh, Regina Poß-Doering, Joachim Szecsenyi, Lorenz Uhlmann and 4 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Anja WollnyInstitute of General Practice, Rostock University Medical Center, Rostock, Germany.
Attila AltinerInstitute of General Practice, Rostock University Medical Center, Rostock, Germany.
Tonia BrandaQua-Institute for Applied Quality Improvement and Research in Health Care GmbH, Göttingen, Germany.
Katharina GarbeInstitute of General Practice, Rostock University Medical Center, Rostock, Germany. katharina.garbe@med.uni-rostock.de.ORCID http://orcid.org/0000-0003-3842-5525
Martina KamradtDepartment of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.
Petra Kaufmann-KolleaQua-Institute for Applied Quality Improvement and Research in Health Care GmbH, Göttingen, Germany.
Mirko LeyhDepartment of Communication Design and Media, University of Applied Sciences, Technology, Business and Design, Wismar, Germany.
Regina Poß-DoeringDepartment of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.
Joachim SzecsenyiDepartment of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.
Lorenz UhlmannDepartment of Medical Biometry, Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany.
Arwed VossDepartment of Communication Design and Media, University of Applied Sciences, Technology, Business and Design, Wismar, Germany.
Dorothea WeberDepartment of Medical Biometry, Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany.
Michel WensingDepartment of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.
Christin LöfflerInstitute of General Practice, Rostock University Medical Center, Rostock, Germany.
Heidelberg University · DEUniversity of Rostock · DEWismar University of Applied Sciences · DE

Funding

Bundesministerium für Gesundheit ZMVI1-2516FSB100
6 · The paper itself

Abstract

backgroundThe overuse of antibiotics is a major cause for the worldwide rise of antibiotic resistance. Although it is well known that acute respiratory tract infections (ARTI) are mainly caused by viruses and are often self limiting, antibiotics are too frequently prescribed in primary care. CHANGE-3 examines whether a complex intervention focusing on improving communication and provision of prescribing feedback reduces antibiotic use in patients suffering from ARTI. METHODS/

designThe CHANGE-3 trial is a cluster-randomized controlled trial nested within a web-based public campaign conducted in two regions in Germany. A total of 114 medical practices will be included. Practices randomized to the intervention will receive a practice-specific antibiotic-prescription feedback and an educational outreach visit. During the visit the whole practice team will receive an introduction to e-learning modules addressing patient-centered communication on antibiotics. Furthermore, the practices will receive tablet PCs with information on antibiotics and the treatment of ARTI to be presented to patients. Practices randomized to the control will provide care as usual. The primary outcome measure is the antibiotic prescribing rate for patients with a history of ARTI. Data collected before the intervention, during the intervention and after the intervention will be compared. The use of narrow- vs. broad-spectrum antibiotics will be analyzed as a secondary outcome. A process evaluation is also part of the trial. DISCUSSION: This study should contribute to the growing body of research on reducing antibiotic prescription.

trial registrationISRCTN, ISRCTN15061174 . Registered retrospectively on 13 July 2018.

Indexed as

Feedback, PsychologicalHabitsPractice Patterns, Physicians'Primary Health CareAnti-Bacterial AgentsAttitude of Health PersonnelCommunicationDrug PrescriptionsEducation, Medical, ContinuingGermanyHealth Knowledge, Attitudes, PracticeHumansInservice TrainingMulticenter Studies as TopicPhysician-Patient RelationsPhysicians, Primary CareAnti-Bacterial AgentsAntibacterial agentsDrug prescriptionsDrug resistancePrimary health careRandomized controlled trialRespiratory tract infections

Identifiers

PMID30728043
PMCPMC6366085
OpenAlexW2920721266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.