Evidence map›Paper›PMID 30728035›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2019

In vitro optimization and comparison of CT angiography versus radial cardiovascular magnetic resonance for the quantification of cross-sectional areas and coronary endothelial function.

Jérôme Yerly, Fabio Becce, Ruud B van Heeswijk, Francis R Verdun, Danilo Gubian, Reto Meuli, Matthias Stuber

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jérôme YerlyDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV and UNIL), Rue du Bugnon 46, Lausanne, 1011, VD, Switzerland. yerlyj.mri@gmail.com.ORCID 0000-0003-4347-8613
Fabio BecceDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV and UNIL), Rue du Bugnon 46, Lausanne, 1011, VD, Switzerland.
Ruud B van HeeswijkDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV and UNIL), Rue du Bugnon 46, Lausanne, 1011, VD, Switzerland.
Francis R VerdunInstitute of Radiation Physics, Lausanne University Hospital (CHUV and UNIL), Lausanne, Switzerland.
Danilo GubianDirection des Constructions, Ingénierie, Technique et Sécurité (CIT-S), Lausanne University Hospital (CHUV and UNIL), Lausanne, Switzerland.
Reto MeuliDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV and UNIL), Rue du Bugnon 46, Lausanne, 1011, VD, Switzerland.
Matthias StuberDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV and UNIL), Rue du Bugnon 46, Lausanne, 1011, VD, Switzerland.
Centre d'Imagerie BioMedicale · CHInstitute of Radiation Physics

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur objectives were first to determine the optimal coronary computed tomography angiography (CTA) protocol for the quantification and detection of simulated coronary artery cross-sectional area (CSA) differences in vitro, and secondly to quantitatively compare the performance of the optimized CTA protocol with a previously validated radial coronary cardiovascular magnetic resonance (CMR) technique.

methods256-multidetector CTA and radial coronary CMR were used to obtain images of a custom in vitro resolution phantom simulating a range of physiological responses of coronary arteries to stress. CSAs were automatically quantified and compared with known nominal values to determine the accuracy, precision, signal-to-noise ratio (SNR), and circularity of CSA measurements, as well as the limit of detection (LOD) of CSA differences. Various iodine concentrations, radiation dose levels, tube potentials, and iterative image reconstruction algorithms (ASiR-V) were investigated to determine the optimal CTA protocol. The performance of the optimized CTA protocol was then compared with a radial coronary CMR method previously developed for endothelial function assessment under both static and moving conditions.

resultsThe iodine concentration, dose level, tube potential, and reconstruction algorithm all had significant effects (all p <  0.001) on the accuracy, precision, LOD, SNR, and circularity of CSA measurements with CTA. The best precision, LOD, SNR, and circularity with CTA were achieved with 6% iodine, 20 mGy, 100 kVp, and 90% ASiR-V. Compared with the optimized CTA protocol under static conditions, radial coronary CMR was less accurate (- 0.91 ± 0.13 mm

conclusionsRadial coronary CMR was more precise and outperformed CTA for the specific task of detecting small CSA differences in vitro, and was able to reliably identify CSA changes an order of magnitude smaller than those reported for healthy physiological vasomotor responses of proximal coronary arteries. However, CTA yielded more accurate CSA measurements, which may prove useful in other clinical scenarios, such as coronary artery stenosis assessment.

Indexed as

Computed Tomography AngiographyMagnetic Resonance ImagingMultidetector Computed TomographyContrast MediaCoronary AngiographyCoronary CirculationCoronary VesselsEndothelium, VascularHumansLimit of DetectionMeglumineOrganometallic CompoundsPhantoms, ImagingPredictive Value of TestsReproducibility of ResultsVasodilationContrast Mediagadoterate meglumineMeglumineOrganometallic CompoundsAccuracyCoronary arteryCross-sectional areaCT angiographyEndothelial functionLimit of detectionPrecisionRadial CMRVasodilationVasomotor response

Identifiers

PMID30728035
PMCPMC6366062
OpenAlexW2921462067

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.