SynthesisReproductive biology and endocrinology : RB&E2019
The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis.
Synthesis in Reproductive biology and endocrinology : RB&E, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimal Stimulation of Hypo-responders Undergoing IVF: a Prospective, Randomized, Controlled Trial
Efficacy and Safety of Biphasic IVM in Low Prognosis Patients Classified as Poseidon Group 1A
Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Comparative Effectiveness of Recombinant Human Follicle-Stimulating Hormone:Recombinant Human Luteinizing Hormone in a 2:1 Ratio versus Highly Purified Human Menopausal Gonadotropin Alone in Ovarian Stimulation for Medically Assisted Reproduction Treatment Using in vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis.Gynecologic and obstetric investigation · 2026Pooled it
- Luteinizing hormone activity in ovarian stimulation: comparative efficacy and safety of gonadotropinsFrontiers in endocrinology · 2026Pooled it
- Recombinant human luteinizing hormone increases endometrial thickness in women undergoing assisted fertility treatments: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Recombinant human luteinizing hormone co-treatment in ovarian stimulation for assisted reproductive technology in women of advanced reproductive age: a systematic review and meta-analysis of randomized controlled trials.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Luteal Phase Support Using Subcutaneous Progesterone: A Systematic Review.Frontiers in reproductive health · 2021Pooled it
- A Randomized Controlled Trial on the Efficacy and Safety of Low-Dose hCG in a Short Protocol with GnRH Agonist and Ovarian Stimulation with Recombinant FSH (rFSH) During the Follicular Phase in Infertile Women Undergoing ART.Reproductive sciences (Thousand Oaks, Calif.) · 2022Trial
- LH supplementation of ovarian stimulation protocols influences follicular fluid steroid composition contributing to the improvement of ovarian response in poor responder women.Scientific reports · 2020Trial
- Recombinant LH supplementation during ovarian stimulation modulates early embryo morphokinetics without affecting IVF outcomes in normal responders: a retrospective time-lapse study.Journal of assisted reproduction and genetics · 2026Article
- Predictive Performance of Oocyte Count for Clinical Pregnancy in GnRH Antagonist IVF Cycles: A Multivariable Analysis of 1171 Fresh Embryo Transfers over a 14-Year Period.Medicina (Kaunas, Lithuania) · 2026Article
- Comparing clinical outcomes of rFSH versus rFSH+HP-hMG in women undergoing in vitro fertilization-embryo transfer in real‑world practice: a retrospective study.Scientific reports · 2026Article
- Article
- Article
- Comparison of Ovarian Stimulation Protocols in Hypogonadotropic Hypogonadism: Case Series and Review of Literature.International journal of women's health · 2026Article
- The role of luteinizing hormone in the management of female infertility: A French Delphi consensus.Journal of assisted reproduction and genetics · 2025Article
- The Association Between Early Progesterone Rise and Serum Estradiol Levels as Well as Endometrial Thickness in IVF Cycles.Journal of clinical medicine · 2025Article
- Serum LH levels before progesterone administration significantly affect pregnancy outcomes in hormone replacement therapy-frozen-thawed embryo transfer cycles.Journal of ovarian research · 2025Article
- Unexpected hypo-responders in in vitro fertilization: The impact of higher gonadotropin doses on oocyte yield.Turkish journal of obstetrics and gynecology · 2025Article
- Introduction: luteinizing hormone for life's journey.Reproductive biology and endocrinology : RB&E · 2025Article
- The role of recombinant LH in ovarian stimulation: what's new?Reproductive biology and endocrinology : RB&E · 2025Review
- The role of LH in follicle development: from physiology to new clinical implications.Reproductive biology and endocrinology : RB&E · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation.
methodsWe performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate.
resultsSignificantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups.
conclusionIn conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.