Evidence map›Paper›PMID 30728003›Full record

Trial reportBMC nephrology2019

The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa.

Nicola Wearne, Charles R Swanepoel, Maureen S Duffield, Bianca J Davidson, Kathryn Manning, Nicki Tiffin, Andrew Boulle, Brian L Rayner, Priyanka Naidu, Ikechi G Okpechi

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. HIV, drugs and the kidney.Drugs in context · 2020
    Review
  2. Current Management Strategies of Chronic Kidney Disease in Resource-Limited Countries.International journal of nephrology and renovascular disease · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nicola WearneDivision of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa. nicola.wearne@uct.ac.za.ORCID 0000-0001-9917-223X
Charles R SwanepoelDivision of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Maureen S DuffieldDivision of Pathology, Department of Clinical Laboratory Services, University of Cape Town, Cape Town, South Africa.
Bianca J DavidsonDivision of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Kathryn ManningDepartment of Medicine, Statistical Analyst, University of Cape Town, Cape Town, South Africa.
Nicki TiffinCIDER: School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Andrew BoulleCIDER: School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Brian L RaynerDivision of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Priyanka NaiduDepartment of Undergraduate Medicine, University of Cape Town, Cape Town, South Africa.
Ikechi G OkpechiDivision of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to assess, the efficacy and safety of add-on corticosteroids to antiretroviral therapy [ART] in patients with biopsy proven HIV associated nephropathy.

methodsAll included patients had histological evidence of either collapsing or non-collapsing focal segmental glomerulosclerosis (FSGS) or podocyte and/or parietal cell hypertrophy or hyperplasia. All patients had evidence of tubulointerstitial inflammation with microcysts. Patients were randomized to ART with the addition of 1 mg/kg of corticosteroids [ART+C] or remained in the group [ART Alone] and followed for 2 years. A repeat biopsy was performed at 6 months.

resultsTwenty-one patients were randomized to [ART+C] and 17 to [ART Alone]. The baseline estimated glomerular filtration rate (eGFR) was significantly lower in the [ART+C] vs. [ART Alone] group [35mls/min/1.73m

conclusionsIn the [ART+C] cohort there was a significant improvement in eGFR over 2-years with increased mortality. Routine corticosteroid use cannot currently be recommended. Further investigation to define which subgroup of this cohort would safely benefit from the positive effects is required.

trial registrationISRCTN study ID ( 56112439 ] was retrospectively registered on the 5 September 2018.

Indexed as

AdultAIDS-Associated NephropathyAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBiopsyDrug Therapy, CombinationFemaleFollow-Up StudiesGlomerular Filtration RateGlomerulosclerosis, Focal SegmentalHumansKaplan-Meier EstimateKidneyMalePrednisoneProspective StudiesAnti-HIV AgentsPrednisoneCorticosteroidsHIVHIV associated nephropathy

Identifiers

PMID30728003
PMCPMC6366071
OpenAlexW2920053620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.