SynthesisBMC infectious diseases2019
Estimating the burden of leptospirosis in Sri Lanka; a systematic review.
Synthesis in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nucleic acid and antigen detection tests for leptospirosis.The Cochrane database of systematic reviews · 2019Pooled it
- Article
- Clinical Experience of Therapeutic Plasma Exchange (TPE) in Severe Leptospirosis: A Case Series from Sri Lanka.Tropical medicine and infectious disease · 2026Article
- Clinical presentation and laboratory findings: key indicators for early diagnosis and severity prediction of leptospirosis in Sri Lanka.BMC infectious diseases · 2026Article
- Molecular epidemiology of rodent-borneJournal of medical microbiology · 2026Article
- Spatiotemporal patterns and climate influences on leptospirosis in Sri Lanka from 2009 to 2024.BMC infectious diseases · 2026Article
- Severe leptospirosis in the intensive care unit: single centre prospective cohort study from Sri Lanka.BMC infectious diseases · 2026Article
- Detection of P1 and P2 Subclades of Leptospira carriage in swine in Sri Lanka.BMC veterinary research · 2025Article
- Application of leptospirosis surveillance study at primary health care center in Banyumas and Demak, Central Java, Indonesia.Open veterinary journal · 2025Article
- The Role of Hydrometeorological Factors in Leptospirosis Transmission in Central Java, Indonesia.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Improving leptospirosis treatment through increased suspicion-"Leptospirosis calendar for general practitioners in Sri Lanka".BMC infectious diseases · 2025Article
- Provider cost estimation of leptospirosis at district general hospital Monaragala, Sri Lanka.BMC infectious diseases · 2025Article
- Secondary sclerosing cholangitis: an unusual presentation of leptospirosis.Tropical medicine and health · 2025Article
- Leptospirosis-Improving Healthcare Outcomes for a Neglected Tropical Disease.Open forum infectious diseases · 2025Review
- Modeling the dynamics of leptospirosis in India.Scientific reports · 2023Article
- Humoral immune response and changes in peritoneal cell populations in rats immunized against two Leptospira serovars; serovar patoc and serovar pyrogenes.BMC immunology · 2023Article
- Pulmonary haemorrhage as a frequent cause of death among patients with severe complicated Leptospirosis in Southern Sri Lanka.PLoS neglected tropical diseases · 2023Observational
- Global, regional, and country-level cost of leptospirosis due to loss of productivity in humans.PLoS neglected tropical diseases · 2023Article
- A Single Clinical Case of Leptospirosis in a 70-Year-Old Man During the Military Conflict in Ukraine.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2023Article
- Ecology and distribution of Leptospira spp., reservoir hosts and environmental interaction in Sri Lanka, with identification of a new strain.PLoS neglected tropical diseases · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundAlthough the assessment of disease burden should be a priority for allocating resources, leptospirosis is grossly underestimated despite its true burden in Sri Lanka. This study aimed to assess the morbidity and mortality of leptospirosis based on routine surveillance data, hospital reported data and scientific publications from Sri Lanka.
methodA systematic review was carried out, and Pub Med, MEDLINE®, BIOSIS Previews, Zoological Record, Web of Science Core Collection, Current Contents Connect, KCI-Korean Journal Database, BIOSIS Citation Index, Data Citation Index, SciELO Citation Index and Google Scholar databases were searched. Quarterly epidemiological bulletin (QEB), indoor morbidity & mortality returns (IMMR) and hand searches of local literature were performed in local libraries. Forty-two relevant full texts, 32 QEBs, and 8 IMMR were included in the full text review. Adjustments were made for under diagnosis, underreporting and chance variability.
resultsThe estimated annual caseload of leptospirosis in Sri Lanka from 2008 to 2015, was 10,423, and the cumulative annual incidence of leptospirosis that required hospitalization was 52.1 (95% CI 51.7-52.6) per 100,000 people. The estimated number of annual deaths due to leptospirosis was approximately 730 (95% CI 542-980), with an estimated pooled case fatality ratio of 7.0% (95% CI 5.2-9.4). The most common organs involved were the kidney, liver and heart, with median rates of 48.7, 30, and 14.2%, respectively.
conclusionOur systematic review shows gross underestimation of the true leptospirosis burden in the national statistics of Sri Lanka, and the hospitalization rates estimated in our study were compatible with the total burden estimate of 300·6 (95% CI 96·54-604·23) per 100,000 people published previously.
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