Evidence map›Paper›PMID 30727864›Full record

ArticleTissue engineering. Part C, Methods2019

Specific, Sensitive, and Stable Reporting of Human Mesenchymal Stromal Cell Chondrogenesis.

Rodolfo E De la Vega, Maximiliano Scheu, Lennart A Brown, Christopher H Evans, Elisabeth Ferreira, Ryan M Porter

Abstract read
In one paragraph

Article in Tissue engineering. Part C, Methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rodolfo E De la Vega1 Department of Orthopaedic Surgery, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Maximiliano Scheu1 Department of Orthopaedic Surgery, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Lennart A Brown1 Department of Orthopaedic Surgery, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Christopher H Evans1 Department of Orthopaedic Surgery, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Elisabeth Ferreira1 Department of Orthopaedic Surgery, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Ryan M Porter1 Department of Orthopaedic Surgery, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Funding

Understanding the Negative Prognostic Impact of Intraosseous Focal Lesions in Multiple MyelomaP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Jesus Delgado-Calle · 2018 to 2026
$23.0M
Facilitating cartilage regeneration by heterogeneous progenitor cellsR00AR057105 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PORTER, RYAN MICHAEL · 2011 to 2013
$726k
A Transgenic Rat for Noninvasive Assessment of Chondrogenic Activity in vivoR21AR069253 · NIAMS · UNIV OF ARKANSAS FOR MED SCIS · PI PORTER, RYAN MICHAEL · 2016 to 2017
$416k
Facilitating cartilage regeneration by heterogeneous progenitor cellsK99AR057105 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PORTER, RYAN MICHAEL · 2009 to 2009
$86k
NIAMS NIH HHS K99 AR057105NIAMS NIH HHS R00 AR057105NIAMS NIH HHS R21 AR069253NIGMS NIH HHS P20 GM125503
6 · The paper itself

Abstract

impact statementThe promoter characterized in this study has been made accessible as a resource for the skeletal tissue engineering and regenerative medicine community. When combined with suitable reporter vectors, the resulting tools can be used for noninvasive and/or high-throughput screening of test conditions for stimulating chondrogenesis by candidate stem/progenitor cells. As demonstrated in this study, they can also be used with small animal imaging platforms to monitor the chondrogenic activity of implanted progenitors within orthotopic models of bone and cartilage repair.

Indexed as

ChondrogenesisOsteogenesisAgedAnimalsBone and BonesCell DifferentiationCells, CulturedChondrocytesFemaleHumansJointsMaleMesenchymal Stem CellsRatsRats, Inbred F344Tissue Engineeringbioluminescence imagingchondrogenesisendochondral ossificationlentiviral vectorsmesenchymal stromal cellsosteochondral defect

Identifiers

PMID30727864
PMCPMC6457328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.