ArticleJournal of experimental botany2019
Field-grown transgenic wheat expressing the sunflower gene HaHB4 significantly outyields the wild type.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Amylase/trypsin inhibitors (ATIs) levels in wheat event IND-ØØ412-7 are similar to non-transgenic wheat.Transgenic research · 2026Article
- Unearthing the hidden organ: vital role of the root in drought tolerance of plants.Plant molecular biology · 2025Review
- From convention to innovation: the role of genetic modification and genome editing in Australian wheat breeding.AoB PLANTS · 2025Review
- Genome-wide characterization and their roles in abiotic stress responses of HD-Zip transcription factors in pepper.BMC plant biology · 2025Article
- Transcriptional gene network involved in drought stress response: application for crop breeding in the context of climate change.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Challenges of translating Arabidopsis insights into crops.The Plant cell · 2025Review
- Latin America: a hub for agrobiotechnological innovations.Annals of botany · 2025Review
- Rewiring gene circuitry for plant improvement.Nature genetics · 2024Review
- A review on strategies for crop improvement against drought stress through molecular insights.3 Biotech · 2024Review
- Article
- Functional and regulatory diversity of homeobox-leucine zipper transcription factors BnaHB6 under dehydration and salt stress in Brassica napus L.Plant molecular biology · 2024Article
- Insights into Salinity Tolerance in Wheat.Genes · 2024Review
- Resistance that stacks up: engineering rust and mildew disease control in the cereal crops wheat and barley.Plant biotechnology journal · 2023Review
- The Transcription Factor HaHB11 Boosts Grain Set and Yield in Rice Plants, Allowing Them to Approach Their Ideal Phenotype.Biomolecules · 2023Article
- From Transgenesis to Genome Editing in Crop Improvement: Applications, Marketing, and Legal Issues.International journal of molecular sciences · 2023Review
- Physiological and molecular insight of microbial biostimulants for sustainable agriculture.Frontiers in plant science · 2023Review
- Sustaining yield and nutritional quality of peanuts in harsh environments: Physiological and molecular basis of drought and heat stress tolerance.Frontiers in genetics · 2023Review
- Improving abiotic stress tolerance of forage grasses - prospects of using genome editing.Frontiers in plant science · 2023Review
- Drought tolerant wheat IND-ØØ412-7 is nutritionally equivalent to its Non-Transgenic Comparator.GM crops & food · 2022Article
- Activation of drought tolerant traits in crops: endophytes as elicitors.Plant signaling & behavior · 2022Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HaHB4 is a sunflower transcription factor belonging to the homeodomain-leucine zipper I family whose ectopic expression in Arabidopsis triggers drought tolerance. The use of PCR to clone the HaHB4 coding sequence for wheat transformation caused unprogrammed mutations producing subtle differences in its activation ability in yeast. Transgenic wheat plants carrying a mutated version of HaHB4 were tested in 37 field experiments. A selected transgenic line yielded 6% more (P<0.001) and had 9.4% larger water use efficiency (P<0.02) than its control across the evaluated environments. Differences in grain yield between cultivars were explained by the 8% improvement in grain number per square meter (P<0.0001), and were more pronounced in stress (16% benefit) than in non-stress conditions (3% benefit), reaching a maximum of 97% in one of the driest environments. Increased grain number per square meter of transgenic plants was accompanied by positive trends in spikelet numbers per spike, tillers per plant, and fertile florets per plant. The gene transcripts associated with abiotic stress showed that HaHB4's action was not dependent on the response triggered either by RD19 or by DREB1a, traditional candidates related to water deficit responses. HaHB4 enabled wheat to show some of the benefits of a species highly adapted to water scarcity, especially in marginal regions characterized by frequent droughts.
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