ArticleEuropean heart journal. Cardiovascular Imaging2019
Determinants and prognostic implications of left ventricular mechanical dispersion in aortic stenosis.
Article in European heart journal. Cardiovascular Imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
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- The left ventricular mechanical dispersion as a marker of disease severity in transthyretin cardiac amyloidosis.Scientific reports · 2025Observational
- Prognostic Impact of Right Ventricular Damage Markers on CT in Patients Undergoing TAVI.Life (Basel, Switzerland) · 2025Article
- Predominant determinants for evaluation of right parasternal approach in transthoracic echocardiography in aortic stenosis: a study based on three-dimensional cardiac computed tomography analysis.The international journal of cardiovascular imaging · 2024Article
- Left ventricular mechanical dispersion as a predictor of the need for pacemaker implantation after transcatheter aortic valve implantation: MeDiPace TAVI study.European heart journal. Cardiovascular Imaging · 2024Article
- The Presence, Location, and Degree of Late Gadolinium Enhancement in Relation to Myocardial Dysfunction and Poor Prognosis in Patients with Systemic Lupus Erythematosus.Journal of cardiovascular development and disease · 2023Article
- An alternative method of indexation in aortic stenosis: height-adjusted effective orifice area : An observational prospective study.Cardiovascular ultrasound · 2023Observational
- Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse.Circulation. Cardiovascular imaging · 2023Article
- The value of myocardial work in the estimation of left ventricular systolic function in patients with coronary microvascular disease: A study based on adenosine stress echocardiography.Frontiers in cardiovascular medicine · 2023Article
- Malignant Mitral Valve Prolapse: Risk and Prevention of Sudden Cardiac Death.Current treatment options in cardiovascular medicine · 2022Article
- 2021 ESC/EACTS Guidelines for the management of valvular heart disease.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Article
- Peak strain dispersion within the left ventricle detected by two-dimensional speckle tracking in patients with uncomplicated systemic lupus erythematosus.The international journal of cardiovascular imaging · 2021Article
- Discordant severity criteria in patients with moderate aortic stenosis: prognostic implications.Open heart · 2021Article
- Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement.Frontiers of medicine · 2021Review
- Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus.Scientific reports · 2020Article
- Left ventricular mechanical dispersion in flow-gradient patterns of severe aortic stenosis with narrow QRS complex.The international journal of cardiovascular imaging · 2020Article
- Observational
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe present study aimed at investigating the association between left ventricular (LV) mechanical dispersion measured with speckle tracking echocardiography and severity of aortic stenosis (AS) and its impact on prognosis. METHODS AND
resultsThis retrospective study included 630 patients [age 72 (62-78) years, 61.4% men] with various grades of AS (mild AS, 19.8%; moderate AS, 37.0%; severe AS, 43.2%). LV mechanical dispersion (defined as standard deviation of time from Q/R on electrocardiogram to peak longitudinal strain in 17 LV segments) was assessed by speckle tracking echocardiography. Clinical, electrocardiographic, and echocardiographic determinants of increased LV mechanical dispersion were evaluated. During a follow-up of 107 (43-133) months, the independent association between LV mechanical dispersion and all-cause mortality (n = 302, 48%) was evaluated including aortic valve replacement as time-dependent co-variate. LV mechanical dispersion increased significantly with increasing severity of AS (mild AS, 54.5 ± 17.2 ms; moderate AS, 56.7 ± 19.3 ms; severe AS, 70.9 ± 24.3 ms; P < 0.001). Independent determinants of increased mechanical dispersion included older age (β = 0.28; P = 0.003), lower LV ejection fraction (β = -0.24; P = 0.020), smaller aortic valve area (β = -8.55; P = 0.001), larger LV mass index (β = 0.20; P < 0.001), and longer QRS duration (β = 1.12 per each 10 ms increase; P = 0.012). LV mechanical dispersion showed incremental prognostic value for all-cause mortality (hazard ratio 1.10 per each 10 ms increase, 95% confidence interval 1.04-1.15; P < 0.001).
conclusionLV mechanical dispersion assessed by speckle tracking echocardiography increases significantly with severity of AS and is significantly associated with all-cause mortality.
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