ArticleAge and ageing2019
Obesity and Longer Term Risks of Dementia in 65-74 Year Olds.
Article in Age and ageing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Late-life body mass index and amyloid interaction on cognitive decline in unimpaired older adults.The journal of prevention of Alzheimer's disease · 2026Trial
- Prevalence, influencing factors, and dementia outcome of sarcopenic obesity in China.Aging clinical and experimental research · 2026Article
- Associations of novel visceral obesity indices (METS-VF and BRI) with dementia: the role of metabolic mediators and genetic susceptibility.Frontiers in nutrition · 2026Article
- High-fat feeding has sex-dependent effects on the structure and biomechanical properties of cerebral parenchymal arterioles and cognitive function.American journal of physiology. Heart and circulatory physiology · 2025Article
- Association between baseline cardio-kidney-metabolic syndrome, its transition and cognitive impairment: result from CHARLS study.Diabetology & metabolic syndrome · 2025Article
- Healthy Cardiovascular Status Attenuates the Detrimental Association Between Osteosarcopenic Adiposity and Alzheimer's Disease-Related Dementia: A UK Biobank Cohort Study.Journal of the American Heart Association · 2025Article
- The Association Between the Weight-Adjusted Waist Index and Dementia Risk in Older Adults: A Prospective Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Association between sarcopenic obesity and dementia in the Chinese elderly using different definitions of obesity: evidence from the CHARLS.Frontiers in aging neuroscience · 2025Article
- Association of zinc deficiency and risk of new-onset dementia: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Trends in all-cause and cause-specific mortality by BMI levels in England, 2004-2019: a population-based primary care records study.The Lancet regional health. Europe · 2024Article
- Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis of Cohort Studies.Psychiatry investigation · 2024Article
- Sarcopenic obesity is part of obesity paradox in dementia development: evidence from a population-based cohort study.BMC medicine · 2024Article
- Pathophysiological Links Between Obesity and Dementia.Neuromolecular medicine · 2023Review
- Microbial lipopolysaccharide-induced inflammation contributes to cognitive impairment and white matter lesion progression in diet-induced obese mice with chronic cerebral hypoperfusion.CNS neuroscience & therapeutics · 2023Article
- Relative importance of potential risk factors for dementia in patients with hypertension.PloS one · 2023Article
- Associations among Body Mass Index, Waist-to-Hip Ratio, and Cognitive Impairment Tend to Follow an Opposite Trend and Are Sex Specific: A Population-Based Cross-Sectional Study in a Rural Area of Xi'an, China.Neuroepidemiology · 2023Article
- Total and regional fat-to-muscle mass ratio and risks of incident all-cause dementia, Alzheimer's disease, and vascular dementia.Journal of cachexia, sarcopenia and muscle · 2022Article
- Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study.Endocrinology and metabolism (Seoul, Korea) · 2021 · on this mapArticle
- A Multimodal Risk Network Predicts Executive Function Trajectories in Non-demented Aging.Frontiers in aging neuroscience · 2021Article
- Severe Dementia Predicts Weight Loss by the Time of Death.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundoverweight or obesity at ages <65 years associates with increased dementia incidence, but at ≥65 years estimates are paradoxical. Weight loss before dementia diagnosis, plus smoking and diseases causing weight loss may confound associations.
objectiveto estimate weight loss before dementia diagnosis, plus short and longer-term body mass index associations with incident dementia in 65-74 year olds within primary care populations in England.
methodswe studied dementia diagnosis free subjects: 257,523 non-smokers without baseline cancer, heart failure or multi-morbidity (group A) plus 161,927 with these confounders (group B), followed ≤14.9 years. Competing hazard models accounted for mortality.
resultsin group A, 9,774 were diagnosed with dementia and in those with repeat weight measures, 54% lost ≥2.5 kg during 10 years pre-diagnosis. During <10 years obesity (≥30.0 kg/m2) or overweight (25.0 to <30.0) were inversely associated with incident dementia (versus 22.5 to <25.0). However, from 10 to 14.9 years, obesity was associated with increased dementia incidence (hazard ratio [HR] 1.17; 95% CI: 1.03-1.32). Overweight protective associations disappeared in longer-term analyses (HR, 1.01; 95% CI: 0.90-1.13). In group B, (n = 6,070 with incident dementia), obesity was associated with lower dementia risks in the short and longer-term.
conclusionsin 65-74 year olds (free of smoking, cancer, heart failure or multi-morbidity at baseline) obesity associates with higher longer-term incidence of dementia. Paradoxical associations were present short-term and in those with likely confounders. Reports of protective effects of obesity or overweight on dementia risk in older groups may reflect biases, especially weight loss before dementia diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.