Evidence map›Paper›PMID 30726853›Full record

ArticleNephron2019

Low Sodium Diet Decreases Stone Formation in Genetic Hypercalciuric Stone-Forming Rats.

Nancy S Krieger, Marc Grynpas, Amy VandenEynde, John R Asplin, Kevin K Frick, Min Ho Kim, Felix M Ramos, Ignacio Granja, David A Bushinsky

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Kidney Stone Prevention.Advances in nutrition (Bethesda, Md.) · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Nancy S KriegerDivision of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA, Nancy_Krieger@urmc.rochester.edu.
Marc GrynpasLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Amy VandenEyndeLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
John R AsplinLitholink Corporation, Laboratory Corporation of America® Holdings, Chicago, Illinois, USA.
Kevin K FrickDivision of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Min Ho KimDivision of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Felix M RamosDivision of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Ignacio GranjaLitholink Corporation, Laboratory Corporation of America® Holdings, Chicago, Illinois, USA.
David A BushinskyDivision of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
University of Rochester · USLink Foundation · USLunenfeld-Tanenbaum Research Institute · CAMount Sinai Hospital · CA

Funding

Hypercalciuria and Bone Quality in the Genetic Hypercalciuric Stone-Forming RatsR01DK075462 · NIDDK · UNIVERSITY OF ROCHESTER · PI BUSHINSKY, DAVID A · 2008 to 2019
$3.8M
NIDDK NIH HHS R01 DK075462
6 · The paper itself

Abstract

backgroundUrine (u) calcium (Ca) excretion is directly dependent on dietary sodium (Na) intake leading to the recommendation for Na restriction in hypercalciuric kidney stone formers. However, there is no direct evidence that limiting Na intake will reduce recurrent stone formation. MATERIALS AND

methodsWe used genetic hypercalciuric stone-forming (GHS) rats, which universally form Ca phosphate (P) kidney stones, fed either a low Na (LNa, 0.05%) or normal Na (NNa, 0.4%) Na diet (D) for 18 weeks. Urine was collected at 6-week intervals. Radiographic analysis for stone formation and bone analyses were done at the conclusion of the study.

resultsMean uCa was lower with LNaD than NNaD as was uP and LNaD decreased mean uNa and uChloride. There were no differences in urine supersaturation (SS) with respect to calcium phosphate (CaP) or Ca oxalate (CaOx). However, stone formation was markedly decreased with LNaD by radiographic analysis. The LNaD group had significantly lower femoral anterior-posterior diameter and volumetric bone mineral density (vBMD), but no change in vertebral trabecular vBMD. There were no differences in the bone formation rate or osteoclastic bone resorption between groups. The LNaD group had significantly lower femoral stiffness; however, the ultimate load and energy to fail was not different.

conclusionThus, a low Na diet reduced uCa and stone formation in GHS rats, even though SS with respect to CaP and CaOx was unchanged and effects on bone were modest. These data, if confirmed in humans, support dietary Na restriction to prevent recurrent Ca nephrolithiasis.

Indexed as

AnimalsHypercalciuriaKidney CalculiRatsSodium, DietarySodium, DietaryMineral metabolismNephrolithiasisSodium

Identifiers

PMID30726853
PMCPMC6546529
OpenAlexW2914411882

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.