Evidence map›Paper›PMID 30726852›Full record

ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2019

Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac Disease.

Muhammet Yener Akpinar, Evrim Kahramanoglu Aksoy, Ferdane Pirincci Sapmaz, Ozlem Ceylan Dogan, Metin Uzman, Yasar Nazligul

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. The Connection between Celiac Disease and Hepatic Steatosis: High Levels of Pigment Epithelium-Derived Factor.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Muhammet Yener AkpinarDepartment of Gastroenterology, Department of Medical Biochemistry, Kecioren Training and Research Hospital, Ankara, Turkey, muhammet.yener@gmail.com.
Evrim Kahramanoglu AksoyDepartment of Gastroenterology, Department of Medical Biochemistry, Kecioren Training and Research Hospital, Ankara, Turkey.
Ferdane Pirincci SapmazDepartment of Gastroenterology, Department of Medical Biochemistry, Kecioren Training and Research Hospital, Ankara, Turkey.
Ozlem Ceylan DoganAnkara University Medical Faculty, Ankara, Turkey.
Metin UzmanDepartment of Gastroenterology, Department of Medical Biochemistry, Kecioren Training and Research Hospital, Ankara, Turkey.
Yasar NazligulDepartment of Gastroenterology, Department of Medical Biochemistry, Kecioren Training and Research Hospital, Ankara, Turkey.
Ankara University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRecent studies have demonstrated that angiogenesis is impaired in patients with celiac disease (CD). In this study, we evaluated the levels of the novel antiangiogenic factor pigment epithelium-derived factor (PEDF) in CD patients.

methodsEighty-four patients were included in the study; 71 patients with CD and 13 healthy controls. In the CD patient cohort, there were 21 newly diagnosed patients, 19 with adherence to a gluten-free diet and 31 practicing no adherence to this diet. The PEDF levels were measured using enzyme-linked immunosorbent assays.

resultsThe data revealed that celiac patients had higher levels of PEDF than did healthy controls. PEDF levels were not significantly different among the three CD groups. Additionally, the PEDF levels were not correlated with tissue transglutaminase IgA or IgG.

conclusionsOur data indicate that PEDF levels are significantly higher in CD patients than those in the healthy controls. This result suggests that PEDF negatively affects angiogenesis in CD. Although we did not observe any differences of PEDF levels among celiac patients, additional studies including more patients could clarify this issue.

Indexed as

AdultCeliac DiseaseCross-Sectional StudiesDiet, Gluten-FreeEye ProteinsFemaleHumansMaleMiddle AgedNerve Growth FactorsPigment Epithelium-Derived FactorProspective StudiesSerpinsEye ProteinsNerve Growth FactorsPigment Epithelium-Derived FactorSerpinsAngiogenesisCeliac diseasePigment epithelium-derived factor

Identifiers

PMID30726852
PMCPMC6597925
OpenAlexW2913144846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.