Evidence map›Paper›PMID 30726833›Full record

ReviewJournal of innate immunity2020

Group 2 Innate Lymphoid Cells in Human Respiratory Disorders.

Esmee K van der Ploeg, Ana Carreras Mascaro, Danny Huylebroeck, Rudi W Hendriks, Ralph Stadhouders

Open access · goldAbstract readReview
In one paragraph

Review in Journal of innate immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Innate Lymphoid Cells Are the Rheostat of Immune Response in the Kidney.Journal of cellular and molecular medicine · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Innate Lymphoid Cells.Advances in experimental medicine and biology · 2025
    Review
  12. Article
  13. Review
  14. Group 2 Innate Lymphoid Cells in Allergic Rhinitis.Journal of inflammation research · 2024
    Review
  15. Article
  16. Article
  17. Type-2 CD8Nature communications · 2023
    Article
  18. Early innate cell interactions withFrontiers in immunology · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Esmee K van der PloegDepartment of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Ana Carreras MascaroDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Danny HuylebroeckDepartment of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Rudi W HendriksDepartment of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Ralph StadhoudersDepartment of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands, r.stadhouders@erasmusmc.nl.
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies using animal models have generated profound insight into the functions of various subsets of innate lymphoid cells (ILCs). The group 2 ILC subset (ILC2) has been implicated in tissue homeostasis, defense responses against parasites, tissue repair, and immunopathology associated with type-2 immunity. In addition, progress has also been made in translating these findings from animal studies into a context of human immunity. Importantly, recent observations strongly support a role for ILC2s in several diseases of the human respiratory system. However, many aspects of human ILC2 biology are still unclear, including how these cells develop and which signals control their activity. As a result, the exact role played by ILCs in human health and disease remains poorly understood. Here, we summarize our current understanding of human ILC2 biology and focus on their potential involvement in various human respiratory disorders.

Indexed as

AnimalsCell DifferentiationCell PlasticityCytokinesDisease Models, AnimalHumansImmunity, InnateLung DiseasesLymphocytesTh2 CellsCytokinesAllergyAsthmaILC2Innate lymphoid cellLungPlasticity

Identifiers

PMID30726833
PMCPMC6959098
OpenAlexW2914154936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.