Evidence map›Paper›PMID 30726761›Full record

ArticleCell metabolism2019

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Saul Soberanes, Alexander V Misharin, Amit Jairaman, Luisa Morales-Nebreda, Alexandra C McQuattie-Pimentel, Takugo Cho, Robert B Hamanaka, Angelo Y Meliton, Paul A Reyfman, James M Walter and 22 more

Abstract readPublished Erratum
In one paragraph

Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Review
  3. Circulating Interleukin-6 Mediates PMResearch (Washington, D.C.) · 2024
    Article
  4. Metformin improvesFrontiers in immunology · 2024
    Article
  5. Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  6. Article
  7. Distinctive features of severe SARS-CoV-2 pneumonia.The Journal of clinical investigation · 2021
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Saul Soberanes
Alexander V Misharin
Amit Jairaman
Luisa Morales-Nebreda
Alexandra C McQuattie-Pimentel
Takugo Cho
Robert B Hamanaka
Angelo Y Meliton
Paul A Reyfman
James M Walter
Ching-I Chen
Monica Chi
Stephen Chiu
Francisco J Gonzalez-Gonzalez
Matthew Antalek
Hiam Abdala-Valencia
Sergio E Chiarella
Kaitlyn A Sun
Parker S Woods
Andrew J Ghio
Manu Jain
Harris Perlman
Karen M Ridge
Richard I Morimoto
Jacob I Sznajder
William E Balch
Sangeeta M Bhorade
Ankit Bharat
Murali Prakriya
Navdeep S Chandel
Gökhan M Mutlu
G R Scott Budinger

Funding

Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2003 to 2019
$30.8M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2018 to 2026
$24.7M
Training Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6M
The injurious effects of hypercapnia on the alveolar epitheliumR01HL085534 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2006 to 2018
$4.9M
Role and Regulation of Sodium, Potasium ATPase in LungR37HL048129 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2008 to 2017
$4.0M
C. elegans Model for Neurodegenerative Diseases of AgingR37AG026647 · NIA · NORTHWESTERN UNIVERSITY · PI MORIMOTO, RICHARD I · 2010 to 2019
$3.9M
Signaling in the lung induced by particulate matter air pollutionR01ES013995 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT · 2006 to 2015
$3.3M
Metabolic Regulation of Epidermal HomeostasisK01AR066579 · NIAMS · UNIVERSITY OF CHICAGO · PI HAMANAKA, ROBERT BRIAN · 2014 to 2018
$424k
The Role of Mitochondrial Reactive Oxygen Species in TGF-Beta SignalingI01BX000201 · VA · JESSE BROWN VA MEDICAL CENTER · PI BUDINGER, GR SCOTT, JAIN, MANU · 2011 to 2017
–
Mitochondrial metabolism as a therapeutic target in pulmonary fibrosisI01CX001777 · VA · JESSE BROWN VA MEDICAL CENTER · PI GR Scott Budinger, MANU JAIN · 2019 to 2026
–
BLRD VA I01 BX000201CSRD VA I01 CX001777NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL085534NHLBI NIH HHS R37 HL048129NHLBI NIH HHS T32 HL076139NIAID NIH HHS U19 AI135964NIAMS NIH HHS K01 AR066579NIA NIH HHS P01 AG049665NIA NIH HHS R37 AG026647NIEHS NIH HHS R01 ES013995
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID30726761
PMCPMC6377562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.