Evidence map›Paper›PMID 30726742›Full record

ArticleCell reports2019

Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis.

Baomei Wang, Jong-Hyung Lim, Tetsuhiro Kajikawa, Xiaofei Li, Bruce A Vallance, Niki M Moutsopoulos, Triantafyllos Chavakis, George Hajishengallis

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Virulence · 2024
    Article
  7. Article
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  11. Article
  12. Review
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  15. Article
  16. Review
  17. Article
  18. ILC3: a case of conflicted identity.Frontiers in immunology · 2023
    Review
  19. Review
  20. Frontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Baomei WangDepartment of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA. Electronic address: baomei.wang@pennmedicine.upenn.edu.
Jong-Hyung LimDepartment of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.
Tetsuhiro KajikawaDepartment of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.
Xiaofei LiDepartment of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.
Bruce A VallanceDepartment of Pediatrics, Division of Gastroenterology, University of British Columbia, Vancouver, BC V6H 3N1, Canada.
Niki M MoutsopoulosOral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.
Triantafyllos ChavakisFaculty of Medicine, Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
George HajishengallisDepartment of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA. Electronic address: geoh@upenn.edu.
University of Pennsylvania · USNational Institute of Dental and Craniofacial Research · USTechnische Universität Dresden · DEUniversity of British Columbia · CA

Funding

Role of complement in kidney disorders: from hemodialysis to transportationP01AI068730 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LAMBRIS, JOHN D · 2007 to 2018
$16.0M
P. gingivalis as a keystone pathogenR01DE015254 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2004 to 2018
$4.6M
Local endogenous regulators of functional immune plasticity in the periodontiumR37DE026152 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2016 to 2025
$3.5M
Neutrophil homeostasis and periodontitis: Novel concepts and treatmentsR01DE024153 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2016 to 2020
$2.0M
Del-1: Molecular and Cellular Targets in PeriodontitisR01DE024716 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2015 to 2019
$2.0M
NIAID NIH HHS P01 AI068730NIDCR NIH HHS R01 DE015254NIDCR NIH HHS R01 DE024153NIDCR NIH HHS R01 DE024716NIDCR NIH HHS R37 DE026152
6 · The paper itself

Abstract

β2-integrins promote neutrophil recruitment to infected tissues and are crucial for host defense. Neutrophil recruitment is defective in leukocyte adhesion deficiency type-1 (LAD1), a condition caused by mutations in the CD18 (β2-integrin) gene. Using a model of Citrobacter rodentium (CR)-induced colitis, we show that CD18

Indexed as

AnimalsCD18 AntigensCitrobacter rodentiumColitisEnterobacteriaceae InfectionsFemaleGene Expression RegulationInflammasomesInterleukin-17Interleukin-1betaInterleukin-22InterleukinsIntestinesMacrophagesMaleMembrane GlycoproteinsCD18 AntigensIl17a protein, mouseIL1B protein, mouseInflammasomesInterleukin-17Interleukin-1betaInterleukin-22InterleukinsLad1 protein, mouseMembrane GlycoproteinsNeuropeptidesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouserac1 GTP-Binding ProteinRac1 protein, mouseReactive Oxygen SpeciesCitrobacter rodentiumcolitisIL-22infectioninflammationinnate immunityinnate lymphoid cellsleukocyte adhesion deficiencymacrophagesβ2-integrins

Identifiers

PMID30726742
PMCPMC6404229
OpenAlexW2913213049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.