ArticleCell reports2019
Mechanism of Acetic Acid Gustatory Repulsion in Drosophila.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Molecular evolution of CO2-sensing ab1C neurons underlies divergent sensory responses in the Drosophila suzukii species group.PLoS genetics · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- An Orco dependent pathway suppresses egg-laying attraction to ripe fruit volatile compounds in Drosophila melanogaster but not in D. suzukii.BMC ecology and evolution · 2025Article
- Gut microbe-derived lactic acid optimizes host energy metabolism during starvation.bioRxiv : the preprint server for biology · 2025Article
- Cholesterol taste avoidance ineLife · 2025Article
- Functional characterization and evolution of olfactory responses in coeloconic sensilla of the global fruit pest Drosophila suzukii.BMC biology · 2025Article
- Amino acids activate parallel chemosensory pathways in Drosophila.Chemical senses · 2025Article
- The conserved IR75 subfamily mediates carboxylic acid detection in insects of public health and agricultural importance.Journal of insect science (Online) · 2025Review
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
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- Lactic acid treatment on infested honey bees works through a local way of action against Varroa destructor.Scientific reports · 2024Article
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- Avoiding alkaline taste through ionotropic receptors.iScience · 2024Article
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- Base Recording: A Technique for Analyzing Responses of Taste Neurons in Drosophila.Journal of visualized experiments : JoVE · 2024Article
- Comparative transcriptome analysis of the antenna and proboscis reveals feeding state-dependent chemosensory genes inOpen biology · 2024Article
- Tastant-receptor interactions: insights from the fruit fly.Frontiers in nutrition · 2024Review
- Mutagenesis of Odorant Receptor CoreceptorInternational journal of molecular sciences · 2023Article
- The power of Drosophila genetics in studying insect toxicology and chemical ecology.Crop health · 2023Review
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Authors and funding
6 authors.
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Abstract
The decision to consume or reject a food based on the degree of acidity is critical for animal survival. However, the gustatory receptors that detect sour compounds and influence feeding behavior have been elusive. Here, using the fly, Drosophila melanogaster, we reveal that a member of the ionotropic receptor family, IR7a, is essential for rejecting foods laced with high levels of acetic acid. IR7a is dispensable for repulsion of other acidic compounds, indicating that the gustatory sensation of acids occurs through a repertoire rather than a single receptor. The fly's main taste organ, the labellum, is decorated with bristles that house dendrites of gustatory receptor neurons (GRNs). IR7a is expressed in a subset of bitter GRNs rather than GRNs dedicated to sour taste. Our findings indicate that flies taste acids through a repertoire of receptors, enabling them to discriminate foods on the basis of acid composition rather than just pH.
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