Evidence map›Paper›PMID 30726535›Full record

ArticleJournal of autism and developmental disorders2019

EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder: A Pilot Cohort Study.

Antonio Gennaro Nicotera, Randi Jenssen Hagerman, Maria Vincenza Catania, Serafino Buono, Santo Di Nuovo, Elisa Maria Liprino, Emanuela Stracuzzi, Stefania Giusto, Giuseppina Di Vita, Sebastiano Antonino Musumeci

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Electroencephalography in Autism Spectrum Disorder.Journal of clinical medicine · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Rodent Models for ASD Biomarker Development.Advances in neurobiology · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Antonio Gennaro NicoteraUnit of Neurology, Oasi Research Institute - IRCCS, via Conte Ruggero 73, Troina, EN, Italy. anicotera@oasi.en.it.
Randi Jenssen HagermanMIND Institute and Department of Pediatrics, University of California Davis Medical Center, Sacramento, CA, USA.
Maria Vincenza CataniaInstitute of Neurological Sciences, The National Research Council of Italy (CNR), Catania, Italy.
Serafino BuonoUnit of Psychology, Oasi Research Institute - IRCCS, Troina, EN, Italy.
Santo Di NuovoDepartment of Educational Sciences, University of Catania, Catania, Italy.
Elisa Maria LiprinoUnit of Neurology, Oasi Research Institute - IRCCS, via Conte Ruggero 73, Troina, EN, Italy.
Emanuela StracuzziUnit of Neurology, Oasi Research Institute - IRCCS, via Conte Ruggero 73, Troina, EN, Italy.
Stefania GiustoUnit of Neurology, Oasi Research Institute - IRCCS, via Conte Ruggero 73, Troina, EN, Italy.
Giuseppina Di VitaUnit of Neurology, Oasi Research Institute - IRCCS, via Conte Ruggero 73, Troina, EN, Italy.
Sebastiano Antonino MusumeciUnit of Neurology, Oasi Research Institute - IRCCS, via Conte Ruggero 73, Troina, EN, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITOasi Maria SS · ITNational Research Council · ITUniversity of California Davis Medical Center · USUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, the phenotypic significance of EEG abnormalities in patients with ASD is unclear. In a population affected by ASD we aimed to evaluate: the phenotypic characteristics; the prevalence of EEG abnormalities; the potential correlations between EEG abnormalities and behavioral and cognitive variables. Sixty-nine patients with ASD underwent cognitive or developmental testing, language assessment, and adaptive behavior skills evaluation as well as sleep/wake EEG recording. EEG abnormalities were found in 39.13% of patients. EEG abnormalities correlated with autism severity, hyperactivity, anger outbursts, aggression, negative or destructive behavior, motor stereotypies, intellectual disability, language impairment and self-harm. Our findings confirmed that EEG abnormalities are present in the ASD population and correlate with several associated phenotypic features.

Indexed as

Severity of Illness IndexAdolescentAggressionAutism Spectrum DisorderBiomarkersChildChild, PreschoolCohort StudiesElectroencephalographyFemaleHumansIntellectual DisabilityMalePilot ProjectsRetrospective StudiesStereotyped BehaviorBiomarkersAutism spectrum disorderBiomarkerEpileptiform abnormalitiesHyperactivityPhenotype

Identifiers

PMID30726535
OpenAlexW2911792122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.