ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2019
TROPHY registry study design: a prospective, international multicenter study for the surgical treatment of posthemorrhagic hydrocephalus in neonates.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The efficacy of ventriculosubgaleal shunt in managing neonatal hydrocephalus due to intraventricular hemorrhage: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Comparing ventricular access devices and ventriculosubgaleal shunts for posthemorrhagic ventricular dilatation: systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- Comparative study between ventriculosubgaleal shunt and external ventricular drain for management of post infective hydrocephalus among pediatrics.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Trial
- Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review.Fluids and barriers of the CNS · 2026Review
- Article
- Volumetric analysis of term-equivalent age MRI in post-haemorrhagic ventricular dilatation reveals association between deep grey matter volume and developmental outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Neuroendoscopic lavage: a single-center retrospective cohort in the USA.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Ventricular Subgaleal Shunt in Children Under Three Months of Age, from Diagnosis to Outcome: A Review After 11 Years of Experience in a French University Hospital.Children (Basel, Switzerland) · 2025Article
- Current Trends in the Treatment of Pediatric Hydrocephalus: A Narrative Review Centered on the Indications, Safety, Efficacy, and Long-Term Outcomes of Available Treatment Modalities.Children (Basel, Switzerland) · 2024Review
- Posthemorrhagic hydrocephalus management in patients with necrotizing enterocolitis: a monocentric experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Perspectives : Understanding the Pathophysiology of Intraventricular Hemorrhage in Preterm Infants and Considering of the Future Direction for Treatment.Journal of Korean Neurosurgical Society · 2023Article
- Neuroendoscopic lavage versus traditional surgical methods for the early management of posthemorrhagic hydrocephalus in neonates.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Treatment Strategies and Challenges to Avoid Cerebrospinal Fluid Shunting for Pediatric Hydrocephalus.Neurologia medico-chirurgica · 2022Review
- Hydrocephalus: historical analysis and considerations for treatment.European journal of medical research · 2022Review
- Protocol for the multicentre prospective paediatric craniectomy and cranioplasty registry (pedCCR) under the auspices of the European Society for Paediatric Neurosurgery (ESPN).Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Neuroendoscopic lavage for the management of neonatal post-haemorrhagic hydrocephalus: a retrospective series.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Endoscopic third ventriculostomy: a feasible treatment option for pediatric hydrocephalus in a high-risk cohort - a single-center report.World journal of pediatric surgery · 2022Article
- TROPHY registry - status report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Neuroendoscopic surgery in neonates - indication and results over a 10-year practice.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Integrated understanding of hydrocephalus - a practical approach for a complex disease.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAmong children with hydrocephalus, neonates with intraventricular hemorrhage (IVH) and posthemorrhagic hydrocephalus (PH) are considered a group with one of the highest complication rates of treatment. Despite continued progress in neonatal care, a standardized and reliable guideline for surgical management is missing for this challenging condition. Thus, further research is warranted to compare common methods of surgical treatment. The introduction of neuroendoscopic lavage has precipitated the establishment of an international registry aimed at elaborating key elements of a standardized surgical treatment.
methodsThe registry is designed as a multicenter, international, prospective data collection for neonates aged 41 weeks gestation, with an indication for surgical treatment for IVH with ventricular dilatation and progressive hydrocephalus. The following initial temporizing surgical interventions, each used as standard treatment at participating centers, will be compared: external ventricular drainage (EVD), ventricular access device (VAD), ventricular subgaleal shunt (VSGS), and neuroendoscopic lavage (NEL). Type of surgery, perioperative data including complications and mortality, subsequent shunt surgeries, ventricular size, and neurological outcome will be recorded at 6, 12, 36, and 60 months.
resultsAn online, password-protected website will be used to collect the prospective data in a synchronized manner. As a prospective registry, data collection will be ongoing, with no prespecified endpoint. A prespecified analysis will take place after a total of 100 patients in the NEL group have been entered. Analyses will be performed for safety (6 months), shunt dependency (12, 24 months), and neurological outcome (60 months).
conclusionThe design and online platform of the TROPHY registry will enable the collection of prospective data on different surgical procedures for investigation of safety, efficacy, and neurodevelopmental outcome of neonates with IVH and hydrocephalus. The long-term goal is to provide valid data on NEL that is prospective, international, and multicenter. With the comparison of different surgical treatment modalities, we hope to develop better therapy guidelines for this complex neurosurgical condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.