Observational studyPloS one2019
Psychological distress mediated the effects of self-stigma on quality of life in opioid-dependent individuals: A cross-sectional study.
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Stigma in substance-based and behavioural addictions: A systematic review.Journal of behavioral addictions · 2025Pooled it
- A systematic review and meta-analysis of psychosocial interventions for persons with comorbid anxiety and substance use disorders.Journal of substance use and addiction treatment · 2024Pooled it
- A randomized controlled trial to improve fathering among fathers with substance use disorders: Fathering in recovery intervention.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2023Trial
- Reciprocal relationships between self-stigma, psychological distress, and suicidality among individuals with schizophrenia: a random intercept cross-lagged panel model with a one-year follow-up.European archives of psychiatry and clinical neuroscience · 2026Article
- Self-stigma and suicide risk mediates the associations of inattention/impulsivity symptoms with psychological distress and quality of life among people with schizophrenia.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Quality of life measures in treatment for active substance misuse: a scoping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Words matter: Stigmatizing language in medical records of individuals electing medication for opioid use disorder.Drug and alcohol dependence · 2025Article
- Longitudinal Associations Between Sluggish Cognitive Tempo and Academic Achievement in Adolescents: A Mediated Moderation Model.Child psychiatry and human development · 2025Article
- Perceived social support and self-stigma as factors of COVID-19 booster vaccination behavior and intention via cognitive coping and emotion regulation among people infected with COVID-19 in Hong Kong.BMC public health · 2025Article
- Advancing readiness for change in substance use for people with substance use disorders using the Kawa model based intervention program: A quasi-experimental study.Hong Kong journal of occupational therapy : HKJOT · 2024Article
- Somebody to Lean on: Understanding Self-Stigma and Willingness to Disclose in the Context of Addiction.International journal of environmental research and public health · 2024Article
- Psychosocial Correlates of Motivation for Abstinence Among People Who Used Drugs After Community Rehabilitation Treatment in China: A Structural Equation Modelling.Psychology research and behavior management · 2024Article
- Leveraging neuroscience education to address stigma related to opioid use disorder in the community: a pilot study.Frontiers in psychiatry · 2024Article
- Online gaming and its effect on academic performance of Bangladeshi university students: A cross-sectional study.Health science reports · 2023Article
- Article
- Preventing comorbidity between distress and suicidality: a network analysis.Npj mental health research · 2023Article
- Patient-centered quality measurement for opioid use disorder: Development of a taxonomy to address gaps in research and practice.Substance abuse · 2022Review
- Prevalence and correlates of self-stigma in Post-Traumatic Stress Disorder (PTSD).European journal of psychotraumatology · 2022Article
- Relationships of Family Emotional Support and Negative Family Interactions with the Quality of Life among Chinese People with Mental Illness and the Mediating Effect of Internalized Stigma.The Psychiatric quarterly · 2021Article
- Prevalence and underlying factors of mobile game addiction among university students in Bangladesh.Global mental health (Cambridge, England) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth stigma and psychological distress affect quality of life (QOL). This study is an attempt to determine the effects of these two factors on QOL and to explore possible mediation effects between psychological distress and self-stigma in opioid-dependent individuals.
methodsThis cross-sectional study comprised 268 consecutive, treatment-seeking opioid-dependent individuals who were interviewed using the brief version of the World Health Organization Quality of Life instrument (WHOQOL-BREF), the Self-Stigma Scale-Short (SSS-S), the Chinese Health Questionnaire-12 (CHQ-12), and the Opiate Treatment Index (OTI). A series of regression models were constructed to determine if the SSS-S and CHQ-12 predict the WHOQOL-BREF scores. Moreover, a comparison of the potential mediation effects of psychological distress (as assessed by the CHQ-12) was made between the SSS-S and the WHOQOL-BREF using the Baron and Kenny procedure (including three separate regressions), along with the Sobel test.
resultsThe CHQ-12 score was predictive of the scores for the four domains and almost all facets of the WHOQOL-BREF except the item, "Dependence on medical aids." Nonetheless, the SSS-S score predicted three of the four facets of the social QOL after adjustment of the CHQ-12 score. Psychological distress completely mediated the relation between self-stigma and the physical, psychological, and environmental domains, and partially mediated the relationship between self-stigma and social QOL (two-tailed Sobel test: p = 0.02 for each domain).
conclusionsPsychological distress has a significant impact on the QOL of treated opioid users. It appears to be a core element in reducing the negative effects of self-stigma on aspects of QOL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.