ArticleMolecular biology of the cell2019
Yeast-to-hypha transition of Schizosaccharomyces japonicus in response to environmental stimuli.
Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Overexpression of a novel gene FCC1 enhances low-pH tolerance of the non-traditional yeast Pichia kudriavzevii.Archives of microbiology · 2025Article
- Horizontal acquisition of prokaryotic hopanoid biosynthesis reorganizes membrane physiology driving lifestyle innovation in a eukaryote.Nature communications · 2025Article
- Schizosaccharomyces versatilis represents a distinct evolutionary lineage of fission yeast.Yeast (Chichester, England) · 2024Article
- Telomere-to-telomere Schizosaccharomyces japonicus genome assembly reveals hitherto unknown genome features.Yeast (Chichester, England) · 2024Article
- Understanding the molecular mechanisms of human diseases: the benefits of fission yeasts.Microbial cell (Graz, Austria) · 2024Article
- Divergence of cytokinesis and dimorphism control by myosin II regulatory light chain in fission yeasts.iScience · 2023Article
- Hyphal Growth inMicrobiology spectrum · 2023Article
- Cell wall dynamics stabilize tip growth in a filamentous fungus.PLoS biology · 2023Article
- JaponicusDB: rapid deployment of a model organism database for an emerging model species.Genetics · 2022Article
- Molecular and comparative genomic analyses reveal evolutionarily conserved and unique features of the Schizosaccharomyces japonicus mycelial growth and the underlying genomic changes.Current genetics · 2021Article
- A modified culture medium and hyphae isolation method can increase quality of the RNA extracted from mycelia of a dimorphic fungal species.Current genetics · 2021Article
- A squalene-hopene cyclase inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Specific Functional Features of the Cell Integrity MAP Kinase Pathway in the Dimorphic Fission YeastJournal of fungi (Basel, Switzerland) · 2021Article
- Review
- Elevated Sporulation Efficiency in Fission YeastJournal of fungi (Basel, Switzerland) · 2021Article
- Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo.Current biology : CB · 2020Article
- Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformans.PLoS genetics · 2020Article
- DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division.Molecular biology of the cell · 2020Article
- Delineating the Rules for Structural Adaptation of Membrane-Associated Proteins to Evolutionary Changes in Membrane Lipidome.Current biology : CB · 2020Article
- Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size.eLife · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many fungal species are dimorphic, exhibiting both unicellular yeast-like and filamentous forms. Schizosaccharomyces japonicus, a member of the fission yeast clade, is one such dimorphic fungus. Here, we first identify fruit extracts as natural, stress-free, starvation-independent inducers of filamentation, which we use to describe the properties of the dimorphic switch. During the yeast-to-hypha transition, the cell evolves from a bipolar to a unipolar system with 10-fold accelerated polarized growth but constant width, vacuoles segregated to the nongrowing half of the cell, and hyper-lengthening of the cell. We demonstrate unusual features of S. japonicus hyphae: these cells lack a Spitzenkörper, a vesicle distribution center at the hyphal tip, but display more rapid cytoskeleton-based transport than the yeast form, with actin cables being essential for the transition. S. japonicus hyphae also remain mononuclear and undergo complete cell divisions, which are highly asymmetric: one daughter cell inherits the vacuole, the other the growing tip. We show that these elongated cells scale their nuclear size, spindle length, and elongation rates, but display altered division size controls. This establishes S. japonicus as a unique system that switches between symmetric and asymmetric modes of growth and division.
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