Evidence map›Paper›PMID 30726120›Full record

ArticleAmerican journal of respiratory and critical care medicine2019

Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials. Bridging Clinical and Patient Perspectives.

Salman Siddiqui, Loren C Denlinger, Stephen J Fowler, Praveen Akuthota, Dominick E Shaw, Liam G Heaney, Louise Brown, Mario Castro, Tonya A Winders, Monica Kraft and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Treatment by biomarker-informed endotype vs guideline care in children with difficult-to-treat asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Clinical Trial Design Innovations for Precision Medicine in Asthma.Advances in experimental medicine and biology · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Exacerbation-Prone Asthma.The journal of allergy and clinical immunology. In practice · 2020
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Salman Siddiqui1 National Institute for Health Research (NIHR) Respiratory Biomedical Research Centre, College of Life Sciences, University of Leicester, Leicester, United Kingdom.ORCID 0000-0003-3770-7870
Loren C Denlinger2 Allergy, Pulmonary, and Critical Care Division, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Stephen J Fowler3 Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, The University of Manchester and NIHR Biomedical Research Centre, Manchester University National Health Service Foundation Trust, Manchester, United Kingdom.
Praveen Akuthota4 Pulmonary Division, Department of Medicine, University of California-San Diego, La Jolla, California.
Dominick E Shaw5 NIHR Biomedical Research Centre, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom.
Liam G Heaney6 Centre for Experimental Medicine, Queens University Belfast, Belfast, United Kingdom.
Louise Brown7 Medical Research Council Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, London, United Kingdom.
Mario Castro8 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Tonya A Winders9 Allergy and Asthma Network, Global Allergy and Asthma Patient Platform, Vienna, Austria.
Monica Kraft10 Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona.
Scott Wagers11 BioSci Consulting, Rijksweg, Belgium.
Michael C Peters12 Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, California.
Ian D Pavord13 Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; and.
Samantha Walker14 Asthma UK and Edinburgh University, Edinburgh, United Kingdom.
Nizar N Jarjour2 Allergy, Pulmonary, and Critical Care Division, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI Nathan J Cherrington · 1994 to 2026
$36.7M
Uncovering Biologic Mechanisms of Severe AsthmaK23HL138303 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PETERS, MICHAEL · 2017 to 2020
$709k
Department of Health EME/16/71/05Medical Research Council MR/M016579/1NHLBI NIH HHS K23 HL138303NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ImmunophenotypingAdultAgedAged, 80 and overAnti-Asthmatic AgentsAsthmaFemaleHumansMaleMiddle AgedPractice Guidelines as TopicPrecision MedicineAnti-Asthmatic Agents

Identifiers

PMID30726120
PMCPMC6835084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.