Evidence map›Paper›PMID 30725537›Full record

Trial reportMolecular nutrition & food research2019

Disentangling the Effects of Monounsaturated Fatty Acids from Other Components of a Mediterranean Diet on Serum Metabolite Profiles: A Randomized Fully Controlled Dietary Intervention in Healthy Subjects at Risk of the Metabolic Syndrome.

Charlotte C J R Michielsen, Roland W J Hangelbroek, Edith J M Feskens, Lydia A Afman

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Charlotte C J R MichielsenDivision of Human Nutrition and Health, Wageningen University, Wageningen, P.O. Box 17, 6700AA, The Netherlands.
Roland W J HangelbroekDivision of Human Nutrition and Health, Wageningen University, Wageningen, P.O. Box 17, 6700AA, The Netherlands.
Edith J M FeskensDivision of Human Nutrition and Health, Wageningen University, Wageningen, P.O. Box 17, 6700AA, The Netherlands.
Lydia A AfmanDivision of Human Nutrition and Health, Wageningen University, Wageningen, P.O. Box 17, 6700AA, The Netherlands.
Wageningen University & Research · NL

Funding

BBMRI-NL 184033111joint programming initiative - 'A healthy Diet for a Healthy Life', by the BioNH call 529051002
6 · The paper itself

Abstract

scopeThe Mediterranean (MED) diet has been associated with a decreased risk of cardiovascular diseases. It is unclear whether this health effect can be mainly contributed to high intakes of monounsaturated fatty acids (MUFA), characteristic for the MED diet, or whether other components of a MED diet also play an important role. METHODS AND

resultsA randomized fully controlled parallel trial is performed to examine the effects of the consumption of a saturated fatty acid rich diet, a MUFA-rich diet, or a MED diet for 8 weeks on metabolite profiles, in 47 subjects at risk of the metabolic syndrome. A total of 162 serum metabolites are assessed before and after the intervention by using a targeted NMR platform. Fifty-two metabolites are changed during the intervention (false discovery rate [FDR] p < 0.05). Both the MUFA and MED diet decrease exactly the same fractions of LDL, including particle number, lipid, phospholipid, and free cholesterol fraction (FDR p < 0.05). The MED diet additionally decreases the larger subclasses of very-low-density lipoprotein (VLDL), related VLDL fractions, VLDL-triglycerides, and serum-triglycerides (FDR p < 0.05).

conclusionThe findings clearly demonstrate that the MUFA component is responsible for reducing LDL subclasses and fractions, and therefore causes an antiatherogenic lipid profile. Interestingly, consumption of the other components in the MED diet show additional health effects.

Indexed as

Diet, MediterraneanBiomarkersBloodFatty Acids, MonounsaturatedFemaleHumansLipidsLipoproteinsMaleMetabolic SyndromeMiddle AgedBiomarkersFatty Acids, MonounsaturatedLipidsLipoproteinscirculating biomarkersclinical trialhumanslipoprotein compositionmetabolomics

Identifiers

PMID30725537
PMCPMC6646913
OpenAlexW2913433391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.