Evidence map›Paper›PMID 30725175›Full record

ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2019

Contractile function of the excised hagfish heart during anoxia exposure.

L A Gatrell, E Farhat, W G Pyle, Todd E Gillis

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

L A GatrellDepartment of Integrative Biology, University of Guelph, Guelph, ON, N1G-2W1, Canada.
E FarhatDepartment of Biology, University of Ottawa, Ottawa, ON, Canada.
W G PyleDepartment of Biomedical Sciences, University of Guelph, Guelph, Canada.
Todd E GillisDepartment of Integrative Biology, University of Guelph, Guelph, ON, N1G-2W1, Canada. tgillis@uoguelph.ca.ORCID 0000-0002-8585-0658
University of Guelph · CAUniversity of Ottawa · CA

Funding

CIHR
6 · The paper itself

Abstract

Pacific hagfish, Eptatretus stoutii, can recover from 36 h of anoxia and their systemic hearts continue to work throughout the exposure. Recent work demonstrates that glycogen stores are utilized in the E. stoutii heart during anoxia but that these are not sufficient to support the measured rate of ATP production. One metabolic fuel that could supplement glycogen during anoxia is glycerol. This substrate can be derived from lipid stores, stored in the heart, or delivered via the blood. The purpose of this study was to determine the effect of glycerol on the contractile function of the excised E. stoutii heart during anoxia exposure. When excised hearts, perfused with metabolite free saline (mf-saline), were exposed to anoxia for 12 h, there was no difference in heart rate, pressure generation (max-dP), rate of contraction (max-dP/dt

Indexed as

AnimalsGlucoseGlycerolHagfishesHeartHypoxiaMyocardial ContractionMyocardiumTriglyceridesGlucoseGlycerolTriglyceridesAnaerobic metabolismContractile functionGlycerolPressure generationWorking heart preparation

Identifiers

PMID30725175
OpenAlexW2913569835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.