Evidence map›Paper›PMID 30725141›Full record

SynthesisIntensive care medicine2019

Acute kidney injury in trauma patients admitted to the ICU: a systematic review and meta-analysis.

Signe Søvik, Marie Susanna Isachsen, Kine Marie Nordhuus, Christine Kooy Tveiten, Torsten Eken, Kjetil Sunde, Kjetil Gundro Brurberg, Sigrid Beitland

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Older age and post-traumatic organ failure a TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  8. Revisiting acute kidney injury outcomes in traumatic brain injury.World journal of critical care medicine · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Bimodal distribution of trauma-related acute kidney injury (TrAKI): A clinical review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Review
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  14. Article
  15. Observational
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Signe SøvikDepartment of Anaesthesia and Intensive Care, Akershus University Hospital, Lørenskog, Norway. signe.sovik@medisin.uio.no.ORCID 0000-0003-4524-2268
Marie Susanna IsachsenMedical Library at Ullevål Hospital, University of Oslo Library, Oslo, Norway.
Kine Marie NordhuusInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Christine Kooy TveitenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Torsten EkenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-5943-4538
Kjetil SundeInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0001-9518-5199
Kjetil Gundro BrurbergDivision for Health Services, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-5920-4652
Sigrid BeitlandDepartment of Anaesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital Ullevål, Oslo, Norway.ORCID 0000-0001-8803-0105

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo perform a systematic review and meta-analysis of acute kidney injury (AKI) in trauma patients admitted to the intensive care unit (ICU).

methodsWe conducted a systematic literature search of studies on AKI according to RIFLE, AKIN, or KDIGO criteria in trauma patients admitted to the ICU (PROSPERO CRD42017060420). We searched PubMed, Cochrane Database of Systematic Reviews, UpToDate, and NICE through 3 December 2018. Data were collected on incidence of AKI, risk factors, renal replacement therapy (RRT), renal recovery, length of stay (LOS), and mortality. Pooled analyses with random effects models yielded mean differences, OR, and RR, with 95% CI.

resultsTwenty-four observational studies comprising 25,182 patients were included. Study quality (Newcastle-Ottawa scale) was moderate. Study heterogeneity was substantial. Incidence of post-traumatic AKI in the ICU was 24% (20-29), of which 13% (10-16) mild, 5% (3-7) moderate, and 4% (3-6) severe AKI. Risk factors for AKI were African American descent, high age, chronic hypertension, diabetes mellitus, high Injury Severity Score, abdominal injury, shock, low Glasgow Coma Scale (GCS) score, high APACHE II score, and sepsis. AKI patients had 6.0 (4.0-7.9) days longer ICU LOS and increased risk of death [RR 3.4 (2.1-5.7)] compared to non-AKI patients. In patients with AKI, RRT was used in 10% (6-15). Renal recovery occurred in 96% (78-100) of patients.

conclusionsAKI occurred in 24% of trauma patients admitted to the ICU, with an RRT use among these of 10%. Presence of AKI was associated with increased LOS and mortality, but renal recovery in AKI survivors was good.

Indexed as

Acute Kidney InjuryHumansHypotensionInflammationIntensive Care UnitsLength of StayRhabdomyolysisRisk FactorsWounds and InjuriesAcute kidney injuryCritical illnessMortalityRisk factorsSystematic reviewWounds and injuries

Identifiers

PMID30725141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.