ReviewIntensive care medicine2019
Organ donation after circulatory death: current status and future potential.
Review in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07421726 (Controlled Terminal Reperfusion With Cold Preservation Solution in the cDCD III Donor), which is not on this map. Cited by 68 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Controlled Terminal Reperfusion With Cold Preservation Solution in the cDCD III Donor
Who cites it
68 citing papers in PubMed, 4 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Critical Care Nurses' Perceptions and Experiences of the Organ Donation Process: A Systematic Review.Nursing open · 2026Pooled it
- Ethical tensions and professional attitudes toward circulatory death organ donation in the ICU: a systematic review.Intensive care medicine · 2025Pooled it
- Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation.Hepatology international · 2024Guideline
- Brain-based arterial pulse pressure threshold for death determination: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Pooled it
- Education and Ethical Guidance for Organ Donation at the End-of-Life: An Ethical Guidance Statement from the Neurocritical Care Society.Neurocritical care · 2026Review
- [Controlled Donation after Circulatory determination of Death (cDCD) : A position paper by the DCD working group of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI)].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- Impact of ex vivo lung perfusion evaluation on donation after circulatory death in lung transplantation.JTCVS techniques · 2026Article
- Association of reduced physician requirements with brain death confirmation pathway duration and organ donation outcomes in the ICU: a retrospective cohort study.BMC anesthesiology · 2026Article
- Factors that create trust in the donation after circulatory death process among surgical personnel: a qualitative descriptive study.BMC health services research · 2026Article
- Article
- Three-Dimensional Bioprinting and Rose-Inspired Medical Applications.Biomimetics (Basel, Switzerland) · 2026Review
- Intensive care staff: the gatekeepers to donation after circulatory death.Intensive care medicine · 2026Article
- Biliary Glutathione as a Potential Marker for Viability Assessment of Cholangiocytes During Normothermic Machine Perfusion of Livers.Artificial organs · 2026Article
- Potential for donation after circulatory death in Germany: a multicenter retrospective study at seven university hospitals.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Best practices along the kidney transplantation clinical journey.Frontiers in transplantation · 2026Article
- Relatives' experiences of end-of-life care and organ donation after controlled circulatory death: a national prospective multicenter study.Critical care (London, England) · 2025Article
- Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function.Nature communications · 2025Article
- New Frontiers in 3D Printing Using Biocompatible Polymers.International journal of molecular sciences · 2025Review
- Organ donation after death determination by circulatory criteria: family members' experiences with withdrawal of life-sustaining measures in Canadian intensive care units.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Article
- Donation After Circulatory Death following Withdrawal of Life-Sustaining Treatments. Are We Ready to Break the Dead Donor Rule?Journal of bioethical inquiry · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The continuing shortage of deceased donor organs for transplantation, and the limited number of potential donors after brain death, has led to a resurgence of interest in donation after circulatory death (DCD). The processes of warm and cold ischemia threaten the viability of DCD organs, but these can be minimized by well-organized DCD pathways and new techniques of in situ organ preservation and ex situ resuscitation and repair post-explantation. Transplantation survival after DCD is comparable to donation after brain death despite higher rates of primary non-function and delayed graft function. Countries with successfully implemented DCD programs have achieved this primarily through the establishment of national ethical, professional and legal frameworks to address both public and professional concerns with all aspects of the DCD pathway. It is unlikely that expanding standard DCD programs will, in isolation, be sufficient to address the worldwide shortage of donor organs for transplantation. It is therefore likely that reliance on extended criteria donors will increase, with the attendant imperative to minimize ischemic injury to candidate organs. Normothermic regional perfusion and ex situ perfusion techniques allow enhanced preservation, assessment, resuscitation and/or repair of damaged organs as a way of improving overall organ quality and preventing the unnecessary discarding of DCD organs. This review will outline exemplar controlled and uncontrolled DCD pathways, highlighting practical and logistical considerations that minimize warm and cold ischemia times while addressing potential ethical concerns. Future perspectives will also be discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.