Evidence map›Paper›PMID 30724834›Full record

ArticleThe Pediatric infectious disease journal2019

HIV-1 Drug Resistance and Virologic Outcomes Among Tanzanian Youth Living With HIV.

Dorothy E Dow, Aisa M Shayo, Coleen K Cunningham, Blandina T Mmbaga

Open access · greenAbstract read
In one paragraph

Article in The Pediatric infectious disease journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Dorothy E DowFrom the Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
Aisa M ShayoKilimanjaro Christian Medical Centre, Moshi, Tanzania.
Coleen K CunninghamFrom the Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
Blandina T MmbagaKilimanjaro Christian Medical Centre, Moshi, Tanzania.
Duke Institute for Health Innovation · USDuke University · USKilimanjaro Christian Medical Centre · TZ

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)R25TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, VERMUND, STEN H. · 2012 to 2016
$6.3M
Institutional Training Grant in Pediatric Infectious DiseaseT32HD060558 · NICHD · DUKE UNIVERSITY · PI CUNNINGHAM, COLEEN K. · 2011 to 2015
$1.0M
Integrating Mental Health into a HIV Clinic to Improve Outcomes in Tanzanian YouthK01TW009985 · FIC · DUKE UNIVERSITY · PI DOW, DOROTHY E. · 2015 to 2019
$667k
FIC NIH HHS K01 TW009985FIC NIH HHS R25 TW009337NIAID NIH HHS P30 AI064518NICHD NIH HHS T32 HD060558
6 · The paper itself

Abstract

Adolescents living with HIV tend to have poor adherence that often breeds HIV resistance mutations and virologic failure (VF). This study evaluated risk behavior, virologic outcomes and HIV resistance mutations in Tanzanian youth living with HIV. Participants were primarily perinatally infected and of mean age 16.7 years; among them 41.5% had VF. Those receiving first-line therapy demonstrated over 90% resistance to their current therapy.

Indexed as

Drug Resistance, ViralAdolescentAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCross-Sectional StudiesFemaleHealth Risk BehaviorsHIV-1HIV InfectionsHumansMaleMedication AdherenceMutationProspective StudiesRisk FactorsRNA, ViralAnti-HIV AgentsRNA, Viral

Identifiers

PMID30724834
PMCPMC6857177
OpenAlexW2912389896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.