ArticleMolecular and cellular biology1988
A yeast gene essential for regulation of spindle pole duplication.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 137 citations in OpenAlex.
- The AMPK kinase Sak1 activates separase and promotes its nuclear localization during mitosis.The Journal of cell biology · 2026Article
- Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells.International journal of molecular sciences · 2023Article
- Separase and Roads to Disengage Sister Chromatids during Anaphase.International journal of molecular sciences · 2023Review
- Mapping separase-mediated cleavage in situ.NAR genomics and bioinformatics · 2022Article
- Structure and Function of the Separase-Securin Complex.Sub-cellular biochemistry · 2021Review
- Characterization of a novel separase-interacting protein and candidate new securin, Eip1p, in the fungal pathogenMolecular biology of the cell · 2019Article
- Separase prevents genomic instability by controlling replication fork speed.Nucleic acids research · 2018Article
- A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition.PLoS genetics · 2015Article
- Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance.Cellular and molecular life sciences : CMLS · 2012Review
- Polyploidy in fungi: evolution after whole-genome duplication.Proceedings. Biological sciences · 2012Review
- Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts.The Journal of biological chemistry · 2010Article
- CAML loss causes anaphase failure and chromosome missegregation.Cell cycle (Georgetown, Tex.) · 2009Article
- Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast.Molecular biology of the cell · 2008Article
- Article
- A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.Genes & development · 2007Article
- Cytoskeleton and morphogenesis in brown algae.Annals of botany · 2006Review
- Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.The Journal of cell biology · 2006Article
- Review
- The functional landscape of mouse gene expression.Journal of biology · 2004Article
- Meiotic double-strand breaks at the interface of chromosome movement, chromosome remodeling, and reductional division.Genes & development · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In eucaryotic cells, duplication of spindle poles must be coordinated with other cell cycle functions. We report here the identification in Saccharomyces cerevisiae of a temperature-sensitive lethal mutation, esp1, that deregulates spindle pole duplication. Mutant cells transferred to the nonpermissive temperature became unable to continue DNA synthesis and cell division but displayed repeated duplication of their spindle pole bodies. Although entry into this state after transient challenge by the nonpermissive temperature was largely lethal, rare survivors were recovered and found to have become increased in ploidy. If the mutant cells were held in G0 or G1 during exposure to the elevated temperature, they remained viable and maintained normal numbers of spindle poles. These results suggest dual regulation of spindle pole duplication, including a mechanism that promotes duplication as cells enter the division cycle and a negative regulatory mechanism, controlled by ESP1, that limits duplication to a single occurrence in each cell division cycle. Tetrad analysis has revealed that ESP1 resides at a previously undescribed locus on the right arm of chromosome VII.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.