Evidence map›Paper›PMID 30724486›Full record

ArticleBrain and behavior2019

Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing.

Kristina M Gicas, Alex Cheng, Iris Rawtaer, Taylor S Willi, William J Panenka, Donna J Lang, Geoff N Smith, Fidel Vila-Rodriguez, Olga Leonova, Chantelle J Giesbrecht and 12 more

Abstract read
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In one paragraph

Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kristina M GicasDepartment of Psychology, Simon Fraser University, Burnaby, Canada.ORCID 0000-0001-7917-6727
Alex ChengDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Iris RawtaerDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Taylor S WilliDepartment of Psychology, Simon Fraser University, Burnaby, Canada.
William J PanenkaDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Donna J LangDepartment of Radiology, University of British Columbia, Vancover, Canada.
Geoff N SmithDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Fidel Vila-RodriguezDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Olga LeonovaDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Chantelle J GiesbrechtDepartment of Psychology, Simon Fraser University, Burnaby, Canada.
Andrea A JonesDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Alasdair M BarrDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancover, Canada.
Ric M ProcyshynDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Tari BuchananDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
G William MacEwanDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Wayne SuDepartment of Psychiatry, University of British Columbia, Vancover, Canada.
Alexandra T VertinskyDepartment of Radiology, University of British Columbia, Vancover, Canada.
Alexander RauscherDepartment of Paediatrics, University of British Columbia, Vancover, Canada.
Norm O'RourkeDepartment of Public Health and Centre for Multidisciplinary Research in Aging, University of the Negev, Be'er Sheva, Israel.
Wendy Loken ThorntonDepartment of Psychology, Simon Fraser University, Burnaby, Canada.
Allen E ThorntonDepartment of Psychology, Simon Fraser University, Burnaby, Canada.
William G HonerDepartment of Psychiatry, University of British Columbia, Vancover, Canada.

Funding

CIHR CBG‐101827
6 · The paper itself

Abstract

objectiveWe investigated white matter differences associated with distinct neurocognitive profiles derived from a large cohort of marginally housed persons with comorbid physical and mental illnesses. Our prior work identified three profile cluster groups: a high functioning group (Cluster 1), a low functioning group with relative strength in decision-making (Cluster 3), and an intermediary group with a relative decision-making weakness (Cluster 2). This study extends previous findings of cortical gray matter differences between these groups with evidence for putative neurodevelopmental abnormalities in the low cognitive functioning group (i.e., Cluster 3). We hypothesized that altered white matter diffusion would be associated with the lowest functioning neurocognitive profile and would be associated with previously observed gray matter differences.

methodParticipants from a socially impoverished neighborhood in Vancouver, Canada underwent neurocognitive evaluation and neuroimaging. We performed Tract-Based Spatial Statistics using diffusion tensor imaging data from 184 participants to examine whole-brain differences in white matter microstructure between cluster analytically derived neurocognitive profiles, as well as unitary neurocognitive measures. Correlations between frontal gray and white matter were also examined.

resultsCluster 3 showed increased diffusion in predominately bilateral frontal and interhemisphere tracts (vs. Clusters 1 and 2), with relatively greater diffusion in the left hemisphere (vs. Cluster 1). Differences in radial diffusivity were more prominent compared with axial diffusivity. A weak association between regional frontal fractional anisotropy and previously defined abnormalities in gyrification was observed.

conclusionsIn a socially marginalized sample, we established several patterns in the covariation of white matter diffusion and neurocognitive functioning. These patterns elucidate the neurobiological substrates and vulnerabilities that are apt to underlie functional impairments inherent to this complex and heterogeneous population.

Indexed as

Gray MatterNeurocognitive DisordersWhite MatterAdultAlmshousesCanadaCognitionCohort StudiesDiffusion Tensor ImagingFemaleHumansMaleMental Status and Dementia TestsMultiple Chronic ConditionsVulnerable Populationsdiffusion tensor imagingmultimorbidityneurocognitionstructural brain imagingwhite matter

Identifiers

PMID30724486
PMCPMC6422717

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.