ArticleMedical science monitor : international medical journal of experimental and clinical research2019
Altered Corneal Nerves in Chinese Thyroid-Associated Ophthalmopathy Patients Observed by In Vivo Confocal Microscopy.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Corneal nerve alterations in migraine: a systematic review of in vivo confocal microscopy and esthesiometry findings.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2026Pooled it
- Corneal Confocal Microscopy to Diagnose Peripheral Neuropathy: A Systematic Review and Meta-Analysis.European journal of neurology · 2025Pooled it
- Review
- Predictive modeling of graves' orbitopathy activity based on meibomian glands analysis using in vivo confocal microscopy.BMC endocrine disorders · 2025Article
- Risk Factors for Ocular Surface Irritation Symptoms in Inactive Mild and Moderate-to-Severe Graves' Orbitopathy.Ophthalmology and therapy · 2024Article
- Clinical associations of corneal neuromas with ocular surface diseases.Neural regeneration research · 2024Review
- Investigation of Conjunctival Goblet Cell and Tear MUC5AC Protein in Patients With Graves' Ophthalmopathy.Translational vision science & technology · 2023Article
- Assessing the corneal sub-basal nerve plexus byAnnals of medicine · 2022Article
- Comprehensive analysis of key genes and pathways for biological and clinical implications in thyroid-associated ophthalmopathy.BMC genomics · 2022Article
- A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration.Cell reports · 2022Article
- In Vivo Confocal Microscopy in Different Types of Dry Eye and Meibomian Gland Dysfunction.Journal of clinical medicine · 2022Review
- Semiautomated and Automated Quantitative Analysis of Corneal Sub-Basal Nerves in Patients With DED With Ocular Pain Using IVCM.Frontiers in medicine · 2022Article
- In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves' orbitopathy.BMC ophthalmology · 2021Article
- Ocular surface changes in Graves' ophthalmopathy.International journal of ophthalmology · 2021Review
- Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid-associated ophthalmopathy.Experimental and therapeutic medicine · 2020Article
- Tear inflammatory cytokines and ocular surface changes in patients with active thyroid eye disease treated with high-dose intravenous glucocorticoids.Journal of endocrinological investigation · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Thyroid-associated ophthalmopathy (TAO) is a common endocrine autoimmune disease. The present study explored corneal nerve changes in TAO patients. MATERIAL AND METHODS Thirty-eight Chinese TAO patients and 20 healthy individuals were included in the study. Central corneal subbasal nerve density and morphology were evaluated with in vivo laser scanning confocal microscopy and quantified using automated CCmetrics software. RESULTS The values of the central corneal subbasal nerve plexus parameters of both active and inactive TAO patients were significantly decreased compared with those of controls, including corneal nerve fiber density (CNFD) (P<0.001 for both), corneal nerve branch density (CNBD) (P<0.001 for both), corneal nerve fiber length (CNFL) (P<0.001 for both), corneal nerve fiber total branch density (CTBD) (P<0.001 for both), corneal nerve fiber area (CNFA) (P<0.001 for both), corneal nerve fiber width (CNFW) (P=0.046, P=0.027, respectively), and corneal nerve fiber fractal dimension (ACNFrD) (P<0.001 for both). In addition, CNFD and ACNFrD values were significantly lower in the active TAO patients compared with those in the inactive TAO patients (P=0.020, P=0.002, respectively). There were significant correlations between CNFD, CNBD, CNFL, CTBD, CNFA, and ACNFrD and the ocular surface parameters and activity assessment items. CONCLUSIONS Abnormal corneal subbasal nerves were observed in both active and inactive Chinese TAO patients, suggesting that nerve degeneration is associated with the disease. However, the exact underlying mechanisms remain to be elucidated.
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