ReviewPhysiology (Bethesda, Md.)2019
Engineering Human Stasis for Long-Duration Spaceflight.
Review in Physiology (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Using Organoids to Unlock the Potential of Human Torpor for Spaceflight.Current stem cell reports · 2026Article
- Neurological complications in microgravity and long duration spaceflight.NPJ microgravity · 2026Review
- Hibernation-Inspired Innovations in Biomedicine: Addressing Aging, Chronic Diseases, and Critical Care.Canadian journal of zoology · 2026Article
- Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit.NPJ microgravity · 2025Review
- Harnessing hibernation: Unlocking nature's secrets for advances in healthy aging, critical care, and space exploration.Annals of the New York Academy of Sciences · 2025Review
- Sedative Agents, Synthetic Torpor, and Long-Haul Space Travel-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- The utility of animal models to inform the next generation of human space exploration.NPJ microgravity · 2025Review
- Review
- Analysis of physiological and biochemical changes and metabolic shifts during 21-Day fasting hypometabolism.Scientific reports · 2024Article
- Structural brain preservation: a potential bridge to future medical technologies.Frontiers in medical technology · 2024Article
- Hypometabolism with the speed of ultrasound.Nature metabolism · 2023Article
- Evolutionary constraint and innovation across hundreds of placental mammals.Science (New York, N.Y.) · 2023Article
- Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats.Frontiers in pharmacology · 2023Article
- Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons.Nature communications · 2022Article
- The Frailty Puzzle: Searching for Immortality or for Knowledge Survival?Frontiers in cellular neuroscience · 2022Review
- Pediatric Hypothermia: An Ambiguous Issue.International journal of environmental research and public health · 2021Review
- Future trends in measuring physiology in free-living animals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Winter is coming: the future of cryopreservation.BMC biology · 2021Review
- Cold-induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm.The EMBO journal · 2020Article
- Shallow metabolic depression and human spaceflight: a feasible first step.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suspended animation for deep-space travelers is moving out of the realm of science fiction. Two approaches are considered: the first elaborates the current medical practice of therapeutic hypothermia; the second invokes the cascade of metabolic processes naturally employed by hibernators. We explore the basis and evidence behind each approach and argue that mimicry of natural hibernation will be critical to overcome the innate limitations of human physiology for long-duration space travel.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.