Evidence map›Paper›PMID 30724129›Full record

ArticlePhysiology (Bethesda, Md.)2019

Electroceutical Targeting of the Autonomic Nervous System.

Charles C Horn, Jeffrey L Ardell, Lee E Fisher

Abstract read
In one paragraph

Article in Physiology (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  6. Article
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  8. Review
  9. Article
  10. Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating.Neuromodulation : journal of the International Neuromodulation Society · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Stretchable, Fully Polymeric Electrode Arrays for Peripheral Nerve Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Charles C HornBiobehavioral Oncology Program, UPMC Hillman Cancer Center , Pittsburgh, Pennsylvania.ORCID 0000-0002-5587-3912
Jeffrey L ArdellUniversity of California- Los Angeles (UCLA) Cardiac Arrhythmia Center, Los Angeles, California.ORCID 0000-0001-9241-0864
Lee E FisherDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.ORCID 0000-0002-9072-3119

Funding

Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4M
Bioelectric monitoring and control of the heartU01EB025138 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDELL, JEFFREY L, KIPKE, DARYL R · 2017 to 2020
$4.0M
Closed-loop neuroelectric control of emesis and gastric motilityU18TR002205 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HORN, CHARLES CHRISTOPHER · 2017 to 2018
$2.1M
Defining gastric vagal mechanisms underlying emetic activation using novel electrophysiological and optical mapping technologyU18EB021772 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HORN, CHARLES CHRISTOPHER, JENKINS, MICHAEL W. · 2015 to 2017
$712k
Distributed electrode system for high-fidelity cardio-neural mappingU18EB021799 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDELL, JEFFREY L, KIPKE, DARYL R · 2015 to 2017
$640k
Optogenetic control of vagal afferent signaling in chemotherapy-induced nausea and emesisR03CA201962 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HORN, CHARLES CHRISTOPHER · 2016 to 2017
$155k
NCATS NIH HHS U18 TR002205NCI NIH HHS R03 CA201962NIBIB NIH HHS U01 EB025138NIBIB NIH HHS U18 EB021772NIBIB NIH HHS U18 EB021799NIH HHS OT2 OD023848
6 · The paper itself

Abstract

Autonomic nerves are attractive targets for medical therapies using electroceutical devices because of the potential for selective control and few side effects. These devices use novel materials, electrode configurations, stimulation patterns, and closed-loop control to treat heart failure, hypertension, gastrointestinal and bladder diseases, obesity/diabetes, and inflammatory disorders. Critical to progress is a mechanistic understanding of multi-level controls of target organs, disease adaptation, and impact of neuromodulation to restore organ function.

Indexed as

AnimalsAutonomic Nervous SystemDiabetes MellitusElectric Stimulation TherapyGastrointestinal DiseasesHeart DiseasesHumansInflammationObesitySpinal Cord StimulationUrinary Bladder DiseasesVagus Nerve Stimulation

Identifiers

PMID30724129
PMCPMC6586833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.