ArticleAmerican journal of physiology. Renal physiology2019
Dietary restriction of iron availability attenuates UPEC pathogenesis in a mouse model of urinary tract infection.
Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Efficacy of lactoferrin in preventing recurrent urinary tract infections in pregnant Egyptian women: a randomized controlled trial.BMC urology · 2025Trial
- The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance.Archives of microbiology · 2025Review
- A 5-HT-mediated urethral defense against urinary tract infections.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dietary zinc deficiency promotes Acinetobacter baumannii lung infection via IL-13 in mice.Nature microbiology · 2024Article
- Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis.JCI insight · 2024Article
- Uropathogen and host responses in pyelonephritis.Nature reviews. Nephrology · 2023Review
- Effects of deferoxamine on intrinsic colistin resistance ofExperimental and therapeutic medicine · 2023Article
- Comparison of predictive effect of the dietary inflammatory index and empirically derived food-based dietary inflammatory index on the menopause-specific quality of life and its complications.BMC women's health · 2023Article
- Cycle Biodynamics of Women's Microbiome in the Urinary and Reproductive Systems.Journal of clinical medicine · 2023Review
- Effect of bovine lactoferrin on recurrent urinary tract infections: in vitro and in vivo evidences.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- High Virulence and Multidrug Resistance ofMicroorganisms · 2022Article
- Single-cell and spatial mapping Identify cell types and signaling Networks in the human ureter.Developmental cell · 2022Article
- Lead acetate versus cadmium sulfate in the modulation of main physiological pathways controlling detrusor muscle contractility in rat.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- The immune responses to differentFrontiers in immunology · 2022Review
- Iron Chelation in Local Infection.Molecules (Basel, Switzerland) · 2021Review
- Recurrent Urinary Tract Infections: Unraveling the Complicated Environment of Uncomplicated rUTIs.Frontiers in cellular and infection microbiology · 2021Review
- Iron Therapeutics in Women's Health: Past, Present, and Future.Pharmaceuticals (Basel, Switzerland) · 2020Review
- The immune response to infection in the bladder.Nature reviews. Urology · 2020Review
- Genomic Characterization of Multidrug-ResistantFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Iron is a critical nutrient required by hosts and pathogens. Uropathogenic Escherichia coli (UPEC), the principal causative agent of urinary tract infections (UTIs), chelate iron for their survival and persistence. Here, we demonstrate that dietary modulation of iron availability limits UPEC burden in a mouse model of UTI. Mice on a low-iron diet exhibit reduced systemic and bladder mucosal iron availability and harbor significantly lower bacterial burden, concomitant with dampened inflammation. Hepcidin is a master regulator of iron that controls iron-dependent UPEC intracellular growth. Hepcidin-deficient mice ( Hamp1
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