Evidence map›Paper›PMID 30724097›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling.

Ajay P Nayak, Tonio Pera, Deepak A Deshpande, James V Michael, Jennifer R Liberato, Shi Pan, Eric Tompkins, Henry P Morelli, Roslyn Yi, Nadan Wang and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Agonist-specific conformational dynamics at the βBritish journal of pharmacology · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. In silico identification of a βProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Anxiolytics for Bronchodilation: Refinements to GABAAmerican journal of respiratory cell and molecular biology · 2022
    Article
  10. Physiological relevance of proton-activated GPCRs.Pflugers Archiv : European journal of physiology · 2022
    Review
  11. Article
  12. OGR1-dependent regulation of the allergen-induced asthma phenotype.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  13. Cooperativity between β-agonists and c-Abl inhibitors in regulating airway smooth muscle relaxation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Ajay P NayakDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Tonio PeraDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Deepak A DeshpandeDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
James V MichaelDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Jennifer R LiberatoDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Shi PanDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Eric TompkinsDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Henry P MorelliDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Roslyn YiDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Nadan WangDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Raymond B PennDepartment of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Thomas Jefferson University · USCenter for Translational Molecular Medicine · NL

Funding

Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PANETTIERI, REYNOLD ALEXANDER · 2013 to 2023
$23.9M
PKA-dependent regulation of airway epithelial functionF32HL139035 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MICHAEL, JAMES · 2018 to 2018
$35k
NHLBI NIH HHS F32 HL139035NHLBI NIH HHS P01 HL114471
6 · The paper itself

Abstract

Ovarian cancer G protein-coupled receptor 1 (OGR1) is a recently deorphanized G protein-coupled receptor shown to signal in response to low extracellular pH (↓pH

Indexed as

MAP Kinase Signaling SystemUp-RegulationAnimalsCell Adhesion MoleculesFemaleHEK293 CellsHumansHydrogen-Ion ConcentrationLorazepamMiceMice, KnockoutMicrofilament ProteinsMyocytes, Smooth MusclePhosphoproteinsReceptors, G-Protein-CoupledRespiratory SystemCell Adhesion MoleculesGPR68 protein, mouseLorazepamMicrofilament ProteinsPhosphoproteinsReceptors, G-Protein-CoupledVasodilator-Stimulated Phosphoproteinairway smooth musclebenzodiazepinedesensitizationOGR1

Identifiers

PMID30724097
PMCPMC6589584
OpenAlexW2914457725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.