Evidence map›Paper›PMID 30723727›Full record

ArticleERJ open research2019

Prospective observational study in patients with obstructive lung disease: NOVELTY design.

Helen K Reddel, Maria Gerhardsson de Verdier, Alvar Agustí, Gary Anderson, Richard Beasley, Elisabeth H Bel, Christer Janson, Barry Make, Richard J Martin, Ian Pavord and 12 more

Registry-linked trialAbstract read
In one paragraph

Article in ERJ open research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02760329 (A NOVEL Observational longiTudinal studY on Patients With Asthma and/or COPD to Describe Patient Characteristics, Treatment Patterns and the Burden of Illness Over Time and to Identify Phenotypes and Endotypes.), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02760329 completednot on this map

A NOVEL Observational longiTudinal studY on Patients With Asthma and/or COPD to Describe Patient Characteristics, Treatment Patterns and the Burden of Illness Over Time and to Identify Phenotypes and Endotypes.

TypeobservationalSponsorAstraZenecaRan2016 to 2023Enrolled12,255ConditionsAsthma, COPD, Chronic Obstructive Pulmonary DiseaseArmsBlood draw, Urine, Lung function measurements, Fractional Exhaled Nitric Oxide (FENO)
3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Prevalence, Diagnostic Utility and Associated Characteristics of Bronchodilator Responsiveness.American journal of respiratory and critical care medicine · 2024
    Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Treatable traits in the NOVELTY study.Respirology (Carlton, Vic.) · 2022
    Article
  16. Article
  17. Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Helen K ReddelWoolcock Institute of Medical Research, University of Sydney, Sydney, Australia.
Maria Gerhardsson de VerdierRespiratory TA, Global Medical Affairs, AstraZeneca, Mölndal, Sweden.
Alvar AgustíRespiratory Institute, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES, Barcelona, Spain.
Gary AndersonLung Health Research Centre, University of Melbourne, Melbourne, Australia.
Richard BeasleyMedical Research Institute of New Zealand, Wellington, New Zealand.ORCID https://orcid.org/0000-0003-0337-406X
Elisabeth H BelAcademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Christer JansonDept of Medical Sciences, Uppsala University, Uppsala, Sweden.
Barry MakeNational Jewish Health and University of Colorado Denver, Denver, CO, USA.ORCID https://orcid.org/0000-0003-4349-8745
Richard J MartinNational Jewish Health and University of Colorado Denver, Denver, CO, USA.
Ian PavordNuffield Dept of Medicine, University of Oxford, Oxford, UK.
David PriceObservational and Pragmatic Research Institute, Singapore and Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK.ORCID https://orcid.org/0000-0002-9728-9992
Christina KeenEarly Clinical Development IMED Biotech Unit, AstraZeneca, Mölndal, Sweden.
Asparuh GardevGlobal Medical Affairs, AstraZeneca, Cambridge, UK.
Stephen RennardEarly Clinical Development, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Alecka SveréusRespiratory TA, Global Medical Affairs, AstraZeneca, Mölndal, Sweden.
Aruna T BansalAcclarogen Ltd, Cambridge, UK.
Lance BrannmanUS Medical Affairs, AstraZeneca, Gaithersberg, MD, USA.
Niklas KarlssonPatient Reported Outcomes, Medical Evidence and Observational Research, Global Medical Affairs, AstraZeneca, Mölndal, Sweden.
Javier NuevoRespiratory TA, Global Medical Affairs, AstraZeneca, Madrid, Spain.
Fredrik NybergMedical Evidence and Observational Research, Global Medical Affairs, AstraZeneca, Mölndal, Sweden.
Simon S YoungPrecision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Jørgen VestboSchool of Biological Sciences, University of Manchester, Manchester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) have overlapping clinical features and share pathobiological mechanisms but are often considered distinct disorders. Prospective, observational studies across asthma, COPD and asthma-COPD overlap are limited. NOVELTY is a global, prospective observational 3-year study enrolling ∼12 000 patients ≥12 years of age from primary and specialist clinical practices in 19 countries (ClinicalTrials.gov identifier: NCT02760329). NOVELTY's primary objectives are to describe patient characteristics, treatment patterns and disease burden over time, and to identify phenotypes and molecular endotypes associated with differential outcomes over time in patients with a diagnosis/suspected diagnosis of asthma and/or COPD. NOVELTY aims to recruit real-world patients, unlike clinical studies with restrictive inclusion/exclusion criteria. Data collected at yearly intervals include clinical assessments, spirometry, biospecimens, patient-reported outcomes (PROs) and healthcare utilisation (HCU). PROs and HCU will also be collected 3-monthly

Identifiers

PMID30723727
PMCPMC6355976

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.