Evidence map›Paper›PMID 30723675›Full record

ArticleMetabolic engineering communications2019

Enzyme-fusion strategies for redirecting and improving carotenoid synthesis in

Hery Rabeharindranto, Sara Castaño-Cerezo, Thomas Lautier, Luis F Garcia-Alles, Christian Treitz, Andreas Tholey, Gilles Truan

Open access · goldAbstract read
In one paragraph

Article in Metabolic engineering communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  4. Metabolic Engineering ofJournal of fungi (Basel, Switzerland) · 2024
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  12. Metabolic engineering ofMetabolic engineering communications · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Hery RabeharindrantoLISBP, Université de Toulouse, CNRS, INRA, INSA, Toulouse, France.
Sara Castaño-CerezoLISBP, Université de Toulouse, CNRS, INRA, INSA, Toulouse, France.
Thomas LautierLISBP, Université de Toulouse, CNRS, INRA, INSA, Toulouse, France.
Luis F Garcia-AllesLISBP, Université de Toulouse, CNRS, INRA, INSA, Toulouse, France.
Christian TreitzSystematic Proteome Research and Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Andreas TholeySystematic Proteome Research and Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Gilles TruanLISBP, Université de Toulouse, CNRS, INRA, INSA, Toulouse, France.
Centre National de la Recherche Scientifique · FRChristian-Albrechts-Universität zu Kiel · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatial clustering of enzymes has proven an elegant approach to optimize metabolite transfer between enzymes in synthetic metabolic pathways. Among the multiple methods used to promote colocalisation, enzyme fusion is probably the simplest. Inspired by natural systems, we have explored the metabolic consequences of spatial reorganizations of the catalytic domains of

Indexed as

CarotenoidsDCW, Dry cell weightEnzyme spatial proximityFPP, Farnesyl pyrophosphateGGPP, Geranyl geranyl pyrophosphateHPLC, High performance liquid chromatographyMetabolic engineeringMetabolic fluxMultidomain enzymesSynthetic biology

Identifiers

PMID30723675
PMCPMC6350077
OpenAlexW2909155258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.