Evidence map›Paper›PMID 30723629›Full record

ArticlePeerJ2019

A gelatin/collagen/polycaprolactone scaffold for skin regeneration.

Lin-Gwei Wei, Hsin-I Chang, Yiwei Wang, Shan-Hui Hsu, Lien-Guo Dai, Keng-Yen Fu, Niann-Tzyy Dai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  6. Advancement inJournal of environmental health science & engineering · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Polycaprolactone as biomaterial for bone scaffolds: Review of literature.Journal of oral biology and craniofacial research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Lin-Gwei Wei *Division of Plastic and Reconstructive Surgery, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, R.O.C.
Hsin-I Chang *Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan, R.O.C.
Yiwei WangBurns Research Group, ANZAC Research Institute, Concord Hospital, University of Sydney, Concord West, NSW, Australia.
Shan-Hui HsuInstitute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, R.O.C.
Lien-Guo DaiDepartment of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, R.O.C.
Keng-Yen FuDivision of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Niann-Tzyy DaiDivision of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Concord Repatriation General Hospital · AUNational Defense Medical Center · TWNational Taiwan University · TWTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA tissue-engineered skin substitute, based on gelatin ("G"), collagen ("C"), and poly(ε-caprolactone) (PCL; "P"), was developed.

methodG/C/P biocomposites were fabricated by impregnation of lyophilized gelatin/collagen (GC) mats with PCL solutions, followed by solvent evaporation. Two different GC:PCL ratios (1:8 and 1:20) were used.

resultsDifferential scanning calorimetry revealed that all G/C/P biocomposites had characteristic melting point of PCL at around 60 °C. Scanning electron microscopy showed that all biocomposites had similar fibrous structures. Good cytocompatibility was present in all G/C/P biocomposites when incubated with primary human epidermal keratinocytes (PHEK), human dermal fibroblasts (PHDF) and human adipose-derived stem cells (ASCs)

conclusionThis study may provide an effective and low-cost wound dressings to assist skin regeneration for clinical use.

Indexed as

Adipose-derived stem cellsCollagenGelatinPoly(ε-caprolactone)(PCL)Skin tissue engineering

Identifiers

PMID30723629
PMCPMC6361006
OpenAlexW2913045232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.