Evidence map›Paper›PMID 30723588›Full record

ArticleOncoimmunology

The regulatory capacity of B cells directs the aggressiveness of CLL.

Audrey Mohr, Marie Cumin, Cristina Bagacean, Pierre Pochard, Christelle Le Dantec, Sophie Hillion, Yves Renaudineau, Christian Berthou, Adrian Tempescul, Hussam Saad and 3 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Audrey MohrUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Marie CuminUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Cristina BagaceanUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Pierre PochardUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Christelle Le DantecUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Sophie HillionUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.ORCID 0000-0002-3354-0981
Yves RenaudineauUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Christian BerthouUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Adrian TempesculUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Hussam SaadDépartement d'Hématologie, CHRU Morvan, Brest, France.
Jacques-Olivier PersUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Anne BordronUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.
Christophe JaminUMR1227, Lymphocytes B et Autoimmunité, Univ Brest, INSERM, Brest, France.ORCID 0000-0002-9494-3223
Inserm · FRCentre Hospitalier Régional Universitaire de Brest · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is associated with abnormal T-cell responses responsible for defective anti-tumor activities. Intriguingly, CLL B cells share phenotypical characteristics with regulatory B (Breg) cells suggesting that they might negatively control the T-cell activation and immune responses. We elaborated an

Indexed as

AggressivenessB cellsCLLRegulatory capacityTLR9

Identifiers

PMID30723588
PMCPMC6350696
OpenAlexW2904822333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.