ArticleOncoimmunology2019
Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg
Lijie Zhai, Erik Ladomersky, Kristen L Lauing, Meijing Wu, Denise M Scholtens, Rohan Savoor, Bin Zhang, Jennifer D Wu, Craig Horbinski, Rimas V Lukas and 2 more
Open access · goldAbstract readComment
In one paragraphArticle in Oncoimmunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors at 2 institutions in 1 country.
Lijie ZhaiDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Erik LadomerskyDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-2008-1907 Kristen L LauingDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-4408-1821 Meijing WuDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Denise M ScholtensDepartment of Preventive Medicine-Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Rohan SavoorDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Bin ZhangDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jennifer D WuDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Craig HorbinskiDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Rimas V LukasDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
David C BinderDepartment of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0003-4400-5455 Derek A WainwrightDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0001-7232-4264 Northwestern University · USUniversity of Colorado Denver · US
Funding
TRAINING PROGRAM IN SIGNAL TRANSDUCTION AND CANCERT32CA070085 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1997 to 2026
$5.7MIDO1 and Immunotolerance in GlioblastomaR01NS097851 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHILTZ, GARY E, WAINWRIGHT, DEREK ALAN · 2016 to 2025
$4.6MTarget MIC shedding to revive anti-tumor immunityR01CA204021 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WU, JENNIFER D · 2016 to 2022
$1.8MNKG2D superagonist co-stimulation to enhance adaptive immunotherapy of cancerR01CA208246 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WU, JENNIFER D · 2016 to 2020
$1.8MThe interaction of IDO and Tregs Leads to Immunosuppression in GliomaR00NS082381 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAINWRIGHT, DEREK ALAN · 2014 to 2016
$735kThe interaction of IDO and Tregs Leads to Immunosuppression in GliomaK99NS082381 · NINDS · UNIVERSITY OF CHICAGO · PI WAINWRIGHT, DEREK ALAN · 2013 to 2014
$173kThe role of IDO and Th17 in an experimental mouse model of gliomaF32NS073366 · NINDS · UNIVERSITY OF CHICAGO · PI WAINWRIGHT, DEREK ALAN · 2011 to 2012
$86kNCI NIH HHS R01 CA204021NCI NIH HHS R01 CA208246NCI NIH HHS T32 CA070085NINDS NIH HHS F32 NS073366NINDS NIH HHS K99 NS082381NINDS NIH HHS R00 NS082381NINDS NIH HHS R01 NS097851
6 · The paper itselfAbstract
Preclinical modeling and gene expression analyses have yielded distinct observations for the role of immune checkpoint, IDO1, in glioblastoma (GBM). Accordingly, our recent work differs with Garg
Indexed as
GlioblastomaBiomarkersHumansIndoleamine-Pyrrole 2,3,-DioxygenaseBiomarkersIndoleamine-Pyrrole 2,3,-Dioxygenasebrain tumorglioblastomaIDOimmunosuppressionimmunotherapyTreg
Identifiers
PMID30723577
PMCPMC6350838
OpenAlexW2904038877
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