Evidence map›Paper›PMID 30723574›Full record

ArticleOncoimmunology

Tumor-associated B cells and humoral immune response in head and neck squamous cell carcinoma.

Axel Lechner, Hans A Schlößer, Martin Thelen, Kerstin Wennhold, Sacha I Rothschild, Ramona Gilles, Alexander Quaas, Oliver G Siefer, Christian U Huebbers, Engin Cukuroglu and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  5. Regulatory B Cells in Tumor Microenvironment.Current issues in molecular biology · 2026
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Axel LechnerDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Hans A SchlößerCologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Martin ThelenCologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Kerstin WennholdCologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Sacha I RothschildDepartment of Internal Medicine, Medical Oncology, University Hospital Basel, Basel, Switzerland.
Ramona GillesInstitute of Transfusion Medicine, University of Cologne, Cologne, Germany.
Alexander QuaasInstitute of Pathology, University of Cologne, Cologne, Germany.
Oliver G SieferJean-Uhrmacher-Institute for Clinical ENT Research, University of Cologne, Cologne, Germany.
Christian U HuebbersJean-Uhrmacher-Institute for Clinical ENT Research, University of Cologne, Cologne, Germany.
Engin CukurogluComputational and Systems Biology, Genome Institute of Singapore, Singapore.
Jonathan GökeComputational and Systems Biology, Genome Institute of Singapore, Singapore.
Axel HillmerInstitute of Pathology, University of Cologne, Cologne, Germany.
Birgit GathofInstitute of Transfusion Medicine, University of Cologne, Cologne, Germany.
Moritz F MeyerDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Jens P KlussmannDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Alexander Shimabukuro-VornhagenCologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Sebastian TheurichCologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Dirk BeutnerDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Michael von Bergwelt-BaildonCologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
University of Cologne · DEUniversity Hospital Cologne · DEGenome Institute of Singapore · SGLudwig-Maximilians-Universität München · DEUniversity Hospital of Basel · CHUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B lymphocytes are important players in immune responses to cancer. However, their composition and function in head and neck squamous cell carcinoma (HNSCC) has not been well described. Here, we analyzed B cell subsets in HNSCC (n = 38), non-cancerous mucosa (n = 14) and peripheral blood from HNSCC patients (n = 38) and healthy controls (n = 20) by flow cytometry. Intratumoral B cells contained high percentages of activated (CD86

Indexed as

B cellshead and neck squamous cell carcinomahumoral immune responsetertiary lymphoid structurestumor-associated antigenstumor microenvironment

Identifiers

PMID30723574
PMCPMC6350680
OpenAlexW2910367647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.