Evidence map›Paper›PMID 30723535›Full record

ArticleOxidative medicine and cellular longevity2019

Red Raspberry Extract Protects the Skin against UVB-Induced Damage with Antioxidative and Anti-inflammatory Properties.

Pei-Wen Wang, Yu-Chen Cheng, Yu-Chiang Hung, Chih-Hung Lee, Jia-You Fang, Wen-Tai Li, Yun-Ru Wu, Tai-Long Pan

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Exploring Anti-Aging Potential ofNanotechnology, science and applications · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Plant Extracts as Skin Care and Therapeutic Agents.International journal of molecular sciences · 2023
    Review
  11. Anti-Inflammatory Activity ofMolecules (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Article
  14. Construction of a Secondary Enclosure for UVB Irradiation of Mice.JID innovations : skin science from molecules to population health · 2023
    Article
  15. Article
  16. Article
  17. TwoMarine drugs · 2022
    Article
  18. Review
  19. Antioxidative Role ofAntioxidants (Basel, Switzerland) · 2022
    Article
  20. Jelly Fig (Antioxidants (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Pei-Wen WangDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Yu-Chen ChengDepartment of Chinese Medicine, College of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung, Taiwan.
Yu-Chiang HungDepartment of Chinese Medicine, College of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung, Taiwan.ORCID 0000-0001-7490-4465
Chih-Hung LeeDepartment of Dermatology, College of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung, Taiwan.ORCID 0000-0001-9804-3874
Jia-You FangPharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan.
Wen-Tai LiNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan.
Yun-Ru WuSchool of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.
Tai-Long PanSchool of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0002-0187-8689
Chang Gung University · TWChang Gung University of Science and Technology · TWChina Medical University · TWNational Research Institute of Chinese Medicine · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extensive exposure to UVB (280-320 nm) is the major risk responsible for various skin injuries. Numerous reports have shown that natural products could demonstrate photochemopreventive efficacy against UVB damage. We investigated the preventive effects and associated molecular mechanisms of red raspberry extract upon UVB-caused damage in human epidermal keratinocytes and a nude mouse model. The protein profiles and immunohistological study on a nude mouse skin indicated that red raspberry extract could prevent UVB-caused cell death and protect the skin against UVB-exposed injury manifested by wrinkling, scaling, tanning, and water loss as well as epidermal thickening. In addition, red raspberry extract application effectively abolished oxidative damage in DNA and attenuated the carbonylation level of proteins, which attributed to the activation of SOD, Nrf2 and its target genes, and HO-1. Red raspberry extract also altered the cells' apoptotic signaling pathways including caspase-3 as well as the inflammatory cascade such as c-jun and attenuated UVB-induced activation of NF-

Indexed as

AnimalsAnti-Inflammatory AgentsAntioxidantsFemaleHumansMiceMice, NudePlant ExtractsRubusSkinUltraviolet RaysAnti-Inflammatory AgentsAntioxidantsPlant Extracts

Identifiers

PMID30723535
PMCPMC6339709
OpenAlexW2906700432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.